Huaxi Hospital Translational Medicine Complex opened! Will greatly shorten the time from research to clinical transformation.

Cover journalist Ning Zhi
On July 18th, the comprehensive building of translational medicine in Huaxi Hospital, the core base of clinical research in the national major scientific and technological infrastructure of translational medicine (Sichuan), was officially opened.
The reporter learned from the scene that there are currently five national-level facilities for translational medicine in China, and the national major scientific and technological infrastructure for translational medicine (Sichuan) is the second national-level facility for translational medicine after Shanghai, and it is also the first national major scientific and technological infrastructure for biotherapy translational medicine.
Journalist visit
How tall is the translational medicine complex?
In the emergency building of west china hospital, through a corridor, you come to the comprehensive building of translational medicine in Huaxi Hospital. The building is divided into two floors underground and 16 floors above ground, with nearly 200 research beds.
On the morning of the 18th, the reporter first came to the laminar flow research ward on the 16th floor of the translational medicine complex of Huaxi Hospital, where there were all kinds of nurses’ stations and treatment rooms, and several patients who had participated in clinical trials were admitted.
The reporter learned that the laminar flow research ward is jointly built and managed by the Department of Hematology and the National Drug Clinical Research Center to carry out clinical research including autologous, blood/non-blood integration. Zhu Jinbing, chief resident physician of laminar flow ward, said that the main feature of laminar flow ward is aseptic management, which filters out germs and other particles in the air through special filtering devices to create a safe environment for patients participating in clinical trials.
Subsequently, the reporter went to the early clinical research ward on the 15th floor, the precision medicine center on the 7th floor, the information center on the 9th floor, etc. Each floor has cutting-edge equipment and a sense of science and technology. For example, a robot can monitor the humidity and temperature of each cabinet at any time; In the intelligent reference room, the staff only need to input the document number, and the equipment can automatically find out the paper document quickly.
Expert interpretation
Help to introduce more domestic innovative drugs.
Li Weimin, Dean of West China Clinical Medical College/West China Hospital of Sichuan University, said that after the comprehensive building of translational medicine in West China Hospital is put into operation, it will significantly enhance the independent innovation ability of translational medicine research in China and shorten the time from basic research to clinical application by 30-50%; In the next 5-10 years, 50-100 candidate biotherapy products will be supported for transformation.
"Huaxi Hospital attaches great importance to original research, basic research and how to turn basic research into clinical application." Li Weimin said that the opening of the comprehensive building of translational medicine in West China Hospital will further promote the transformation of basic research into clinical application. "China’s drugs are mainly generic drugs, and there are fewer original drugs with independent intellectual property rights. In the future, we will be able to produce more domestic original new drugs by transforming the large facilities of the comprehensive medical building. On the other hand, the price of original new drugs may be lower, thus benefiting more people."
Wei Yuquan, academician of China Academy of Sciences, director of west china hospital Clinical Cancer Center and director of the State Key Laboratory of Biotherapy, said that the comprehensive building of translational medicine in West China Hospital will accelerate the transformation of basic research into clinic and industry. "The bottleneck of our current biomedicine is that basic research and clinical transformation are not closely applied. After the establishment of major facilities, it can speed up the transformation and increase the scale of transformation. "
Frequent highlights
It has three sharp tools to lead the national biotherapy transformation.
The National Major Science and Technology Infrastructure of Translational Medicine (Sichuan) is the largest biotherapy translational medicine research center with the highest comprehensive integration, the most advanced equipment and high openness and sharing in China, and it has three sharp tools to lead the biotherapy transformation in China.
First, the accurate imaging and evaluation service chain runs through the whole process of "basic discovery-clinical research-achievement transformation-industrial development".
As an important part of this chain, the precision imaging center is one of the few clinical imaging research centers in the world that integrates first-class equipment such as 7T magnetic resonance, magnetoencephalography and PET-MRI. Have the research and development ability to lead the international advanced technology. In addition, precision medicine center is the core component of clinical detection module of translational medicine facilities, and it is one of the important strategic development directions of Huaxi Hospital. The center has built three top platforms, namely high-throughput sequencing, single cell sequencing and bioinformatics analysis. It has the most complete and advanced second-generation and third-generation sequencing systems of Illumina, Ion Torrent, Huada and Oxford Nanopore series, 10X Genomics single-cell database building system and high-performance server in the world, mainly carrying out scientific research and clinical testing services based on whole genome, whole exon group and gene panel sequencing. It has undertaken the whole genome sequencing task of a cohort study of 100,000 natural people in West China Hospital. The single detection flux can reach 140 people and the data analysis takes 15 minutes per person. Its sequencing and analysis ability is the first in medical institutions in China, and it has more than 1 million sample resources available for sequencing research.
Second, the national drug clinical trial institution (clinical trial center) is an innovative clinical trial research platform with "one-stop" bags.
As an innovative clinical trial research platform with full functional integration, all-round open sharing and one-stop bag-carrying, the national drug clinical trial institution has 21 full-time research doctors with rich clinical and research experience, 187 special research beds and 4 ICU standard rescue wards. The platform integrates the functions of clinical research ward, follow-up center, integrated management of subjects’ research data, clinical examination, endoscopy, imaging and pathology. Intelligent clinical trial system operation, free inspection, green reservation channel, rapid admission process, professional researcher project implementation, the main implementation links of clinical trials can be completed in the Translational Medicine Building in a "one-stop" manner, thus accelerating the implementation of clinical trial projects. In addition to facing the supporting units, the platform is also open to universities, research institutes, enterprises, hospitals and other institutions to realize the whole society.
Third, the large-scale preparation center of biological agents is a "clinical cell preparation factory".
The large-scale preparation center of biological agents is equipped with a number of the most advanced fully automatic and fully closed cell preparation production lines, and the environment of the core area of cell preparation reaches B+A level. According to the latest industry standards and development trends at home and abroad, it is equipped with a large number of advanced cell production, storage and inspection equipment, such as advanced fully automatic cell processing workstations, fully sealed C+ isolators, large-scale cell extraction and purification systems, liquid nitrogen-free refrigeration systems and flow cell sorters, at a cost of 160 million RMB, reaching the domestic leading level. Mainly aimed at the clinical transformation research of cell therapy, it realizes the preparation, quality control and research and development of various immune cells, including CAR-T, NK (natural killer cells) and umbilical cord blood and mesenchymal stem cells. It is a modern, standardized and large-scale "clinical cell preparation factory".
Transformation case
Huaxi Hospital released two major transformation achievements.
At the launching ceremony, west china hospital released two major transformation achievements.
One originated from the team of Academician Wei Yuquan. The recombinant protein COVID-19 vaccine, developed by the team of Academician Wei Yuquan, is based on the precise design of structural biology, targeting the binding site between novel coronavirus and human cells. By using insect cells to multiply in culture medium, the gene of new coronavirus is introduced into insect cells to produce high-quality recombination vaccines protein. At present, the phase III clinic of the vaccine is cooperating with Japan, Nepal, Kenya, Indonesia, Bahrain, Belarus, Uzbekistan, Mexico and other countries.
The other is from Professor Liu Jin’s team. The team obtained the certificate of Class 1.1 new anesthetic drug and the contract fund of 500 million yuan to start the research and development of skeletal muscle relaxation drugs, and won the "Innovation and Transformation Award" in west china hospital in 2021 respectively. Among them, phosphopropofol disodium for injection was successfully approved as the "Drug Registration Certificate" for Class I new drugs, which is the first new drug certificate with independent intellectual property rights obtained by Huaxi Hospital.
Reporting/feedback

Unity and struggle is the only way for Chinese people to create great historical achievements-forge ahead in a new journey and create new great achievements.

  (1)

  "In the face of profound and complex changes in the international and domestic environment, we must be calm, maintain our strength, strive for progress steadily, act positively, unite and dare to struggle." At the two sessions of the National People’s Congress, the General Secretary of the Supreme Leader profoundly expounded the new goals, new situation and new tasks of China’s development, emphasizing: "Only when all the people are thinking in one place, making efforts in one place, helping each other in the same boat, being United in one mind, being brave in struggle and being good at struggle, can they continuously win new and greater victories."

  The grand goal of building a strong country and national rejuvenation is encouraging and inspiring. The 20th National Congress of the Communist Party of China defined the objectives and tasks of the development of the cause of the Party and the country in the new era and new journey, and called on the whole party, the whole army and the people of all nationalities in China to unite and struggle for building a socialist modern country in an all-round way and promoting the great rejuvenation of the Chinese nation in an all-round way. Looking at today’s China, from the ambitious feat of bravely climbing the peak of the world’s science and technology to the concerted efforts to achieve a major decisive victory in epidemic prevention and control, from the rain or shine to create a better life to the unremitting struggle to promote high-quality development … … More than 9.6 million square kilometers of hot land are thriving and full of vitality, and more than 1.4 billion people are high-spirited and tenacious, and they have gathered into a torrent of China’s high spirits and forge ahead in the new era.

  Strength comes from unity, and happiness comes from struggle. General Secretary of the Supreme Leader profoundly pointed out in the Party’s Report to the 20th CPC National Congress that "United struggle is the only way for Chinese people to create great historical achievements". This important conclusion profoundly reveals the important password of why we succeeded in the past and how we can continue to succeed in the future, and profoundly demonstrates the confidence and determination of the century-old party to lead hundreds of millions of people to unswervingly advance the historical process of the great rejuvenation of the Chinese nation.

  Looking back on the century-long struggle, our party united and led the people of China to achieve great victories in the new-democratic revolution, socialist revolution and construction, reform and opening up, and socialist modernization, and ushered in a new era in Socialism with Chinese characteristics. Looking at the road ahead, we know that the great rejuvenation of the Chinese nation can not be achieved easily, and we must be prepared to make more arduous and arduous efforts. Follow the main road to Wan Li. No matter how the situation changes, no matter how severe the challenge is, we must anchor the central task of the Party in the new era and new journey, firmly grasp the requirements of the times of unity and struggle, strengthen historical self-confidence, enhance historical initiative, unite as one, unite as one, strive to achieve the set goals with perseverance, and unremittingly promote the great rejuvenation of the Chinese nation with a sober mind.

  The century-old achievements are brilliant, and the century-old big party is in its prime. The best tribute to the history of a hundred years of struggle is to write a new history of struggle.

  (2)

  This scene is full of tears.

  On February 4, 2022, the opening ceremony of Beijing Winter Olympics was held in the National Stadium. Accompanied by My People,My Country’s melodious melody, all walks of life, advanced model figures and representatives of 56 nationalities in China slowly passed the bright five-star red flag to the flag-raising area of the stadium with their hands. This is a powerful interpretation of the unity spirit of hundreds of millions of people and a beautiful presentation of the struggle figure in the new era.

  History has witnessed magnificent progress, and time has engraved solid steps. Since the 18th National Congress of the Communist Party of China, Socialism with Chinese characteristics has entered a new era. In the face of the complicated situation in which the situation in the past century and the epidemic situation in the century are superimposed and the world has entered a new period of turmoil and change, and faced with risks and challenges that are rare in the world and history, the CPC Central Committee with the Supreme Leader as the core sized up the situation, made bold choices, forged ahead, overcame difficulties, United and led the whole party, the whole army and the people of all ethnic groups across the country to set up their sleeves and go forward, rain or shine, bravely singing the magnificent triumph of "the wind blows the red flag over the mark" and struggling to write.

  It is hard to forget that in the second decade of the 21st century, China’s economic development is facing a complicated situation of "three-phase superposition" of growth rate shift period, structural adjustment pain period and early stimulus policy digestion period. At that time, after the aftermath of the international financial crisis, various voices such as Thucydides Trap and Tacitus appeared one after another, and various arguments such as "China threat theory", "China collapse theory" and "China stagnation theory" were endless. Our party put forward that China’s economic development has entered a new normal, put forward and implemented new development concepts, and led the people to boldly turn back the waves and sail against the wind on the voyage of promoting high-quality development, writing a new chapter in the "two miracles";

  It is hard to forget that poverty alleviation has entered the critical period of decisive battle, and the rest are the most difficult hard bones. Faced with the "additional test questions" that followed one after another, the decisive battle against poverty was tight, demanding and heavy, and the CPC Central Committee organized and launched a massive people’s war against poverty. The Party has led the people to overcome difficulties, carry forward the spirit of nailing, dare to gnaw at hard bones, overcome one poverty after another, win the biggest battle against poverty in human history, and create another miracle in history.

  难以忘记,世纪疫情来势汹汹,人民生命安全和身体健康面临严重威胁。我们党始终坚持人民至上、生命至上,以强烈的历史担当和强大的战略定力,因时因势优化调整防控政策措施,高效统筹疫情防控和经济社会发展。中国共产党团结带领亿万人民同舟共济、同心抗疫,成功避免了致病力较强、致死率较高的病毒株的广泛流行,有效保护了人民群众生命安全和身体健康,创造了人类文明史上人口大国成功走出疫情大流行的奇迹;

  难以忘记,历经7年艰辛努力,北京冬奥会、冬残奥会胜利举办。在全球疫情大流行背景下,党中央领导全党全国人民克服各种困难挑战,全部参与者坚持“一刻也不能停,一步也不能错,一天也误不起”,付出了艰苦卓绝的努力,向世界奉献了一届简约、安全、精彩的奥运盛会,全面兑现了对国际社会的庄严承诺;

  … … … …

  When the sea flows, you will show your true colors as a hero; Ride the wind and waves, and you will know more about top gun. Looking back on the extraordinary and unusual journey of this decade, the General Secretary profoundly pointed out: "The great achievements of the new era are made by the party and the people together!" "Over the years, all kinds of risks and challenges we have faced have come one after another, one after another, and every battle has been won by the United struggle and tenacious struggle of all the people."

  In this decade, the task of reform, development and stability is unprecedented. In the arduous struggle, our party has taken charge of great struggles, great projects, great undertakings and great dreams, promoted the overall layout of the "five in one" as a whole, coordinated the promotion of the "four comprehensive" strategic layout, and United and led hundreds of millions of people to push forward Socialism with Chinese characteristics in the new era with a spirit of hard work. Respect the people’s initiative and promote the reform in important areas and key links; Stimulate the whole society to create vitality and take solid steps to promote high-quality development; Put forward the important exposition of people’s democracy in the whole process, and promote the vitality of Socialism with Chinese characteristics’s democratic politics in the new era; Improve the social governance system of co-construction, co-governance and sharing, and promote the construction of safe China to a higher level … … Ten years of hard work is precisely because the United struggle of the Party and the people has gathered the surging momentum of career development and created the great achievements of Socialism with Chinese characteristics in the new era.

  In this decade, the number of contradictory risks and challenges is unprecedented. Facing the dangers of beach-related, climbing and breaking through customs, we have waged a great struggle with many new historical characteristics. Our party has relied on the people closely to stabilize the economy, promote development, fight poverty, build a well-off society, control epidemics, resist major disasters, cope with emergencies and turn crises into crises, overcome seemingly insurmountable difficulties and obstacles, and created amazing miracles on earth. When the Wuhan Defence War started, the phrase "I am party member, I will go first" condensed the concerted efforts to fight the epidemic; After the earthquake in Luding, Sichuan, the rescue team grasped the rope and climbed across the river, showing a new era of "flying Luding Bridge"; Before the mountain fire in Chongqing, the headlights of thousands of volunteers formed a defense line to intercept the fire, and built a "new Great Wall" … … It is precisely because of the United struggle of the Party and the people that we have forged ahead in the past ten years that we have gathered a powerful force to overcome difficulties, and Socialism with Chinese characteristics’s career ship has broken waves and made unremitting efforts.

   

  In our new era, everyone is both a witness and a participant. Feeling the pulse of the times, listening to the rhythm of history, adding the glory of the times and creating the splendor of history, one conclusion is particularly clear: the historic achievements and changes in the cause of the party and the state depend on the strong leadership of the CPC Central Committee with the supreme leader as the core and on the United struggle of the whole party, the whole army and the people of all ethnic groups throughout the country.

  (3)

  The greatness of the cause lies not only in the brilliance of the achievement, but also in the magnificence of the process.

  "Unity formed around a clear goal of struggle is the strongest unity, and struggle based on close unity is the most powerful struggle." This is an important conclusion of the great achievements of the new era in the past ten years, and it is also a profound inspiration for creating new great achievements on the new journey.

  — — Goals guide the direction and inspire hundreds of millions of people to think in one place.

  Ten years of unremitting struggle, how many ups and downs, how many thrilling, how many determined to move forward. Adhere to "the people’s yearning for a better life is our goal" and constantly enhance the people’s sense of acquisition, happiness and security; It is proposed that the overall goal of comprehensively deepening reform is to "improve and develop the Socialism with Chinese characteristics system, promote the modernization of the national governance system and governance capacity", and promote the reform with all-round efforts, multiple breakthroughs, steady and in-depth progress; It is clear that the overall goal of comprehensively promoting the rule of law is to "build Socialism with Chinese characteristics’s rule of law system and build a socialist country ruled by law", and strive to make the people feel fair and just in every legal system, every law enforcement decision and every judicial case; Clarify the strategic policy of strictly administering the party in an all-round way, put forward the general requirements for party building in the new era, and "build the party into a Marxist ruling party that always walks in the forefront of the times, is sincerely supported by the people, is brave in self-revolution, can withstand all kinds of storms, and is full of vitality", opening up a new realm of self-revolution of the century-old big party; It is clear that the party’s goal of strengthening the army in the new era is to "build a people’s army that listens to the party’s command, can win battles and has a good style of work, and build the people’s army into a world-class army", so as to promote the revolutionary reshaping of the people’s army as a whole, reorganize its luggage and start again … …

  One by one, bearing in mind the grand goal of the initial mission, the key choice of raising the flag again and again, and the long-term strategic planning fully demonstrate the grandeur, foresight and greatness of the Supreme Leader General Secretary as a Marxist politician, thinker and strategist, and point out the way forward for the United struggle of the whole party, the whole army and the people of all ethnic groups throughout the country. It is under the banner of the Party that we March forward in unison, unite with one heart under the Party’s goal, and move forward with confidence under the strong leadership of the Party that we constantly create a new situation in the cause of Socialism with Chinese characteristics.

  General Secretary of the Supreme Leader stressed: "From now until the middle of this century, it is the central task of the whole party and people to build a socialist modern power in an all-round way and promote the great rejuvenation of the Chinese nation in an all-round way." The 20th National Congress of the Communist Party of China drew a grand blueprint for building a socialist modern country in an all-round way and promoting the great rejuvenation of the Chinese nation in an all-round way with Chinese modernization, and set the overall goal of China’s development by 2035 and the main goals and tasks in the next five years, which sounded the clarion call for United struggle on the land of China. In the new era and new journey, as long as we are United as a "hard piece of steel" under the banner of the Party, we will be able to turn the grand blueprint into a beautiful reality step by step by putting the major decision-making arrangements made by the 20th Party Congress into action and seeing results.

  — — The core cohesive force has led more than 1.4 billion people to twist into a rope.

  We are such a big party and such a big country. Only when the Party Central Committee has authority can we firmly unite the whole party, and then closely unite the people of all ethnic groups throughout the country to form an invincible and powerful force. Since the 18th National Congress of the Communist Party of China, the Party Central Committee with the Supreme Leader as the core has made every effort to promote the Party’s political construction, improved various systems for safeguarding the authority of the Party Central Committee and centralizing and unifying leadership, ensured that the whole Party maintains a high degree of consistency with the Party Central Committee in political stance, political direction, political principles and political road, and significantly enhanced the Party’s political leadership, ideological leadership, mass organization and social appeal. It is the common choice, solemn choice and inevitable choice of the history and the people to establish the core position of the Supreme Leader, the comrades of the CPC Central Committee and the whole party, and it is the luck of the party and the country, the people and the Chinese nation. Take a firm direction in flying clouds, be rock-solid in stormy waves, strategize in risk challenges, calmly control all kinds of complicated situations, and effectively deal with all kinds of risk challenges at home and abroad … … Practice has fully proved that with General Secretary of the Supreme Leader at the helm, more than 1.4 billion people in China will have a leader in United struggle.

  "Building a socialist modern country in an all-round way is a great and arduous undertaking with a bright future and a long way to go." The 20th National Congress of the Communist Party of China (CPC) must be prepared to stand the major test of high winds, high waves and even stormy waves, and put forward the major principles that must be firmly grasped, with "upholding and strengthening the overall leadership of the Party" as the first priority. In the new era and new journey, we will more consciously safeguard the core position of the CPC Central Committee, General Secretary of the Supreme Leader, the core position of the whole Party, the authority and centralized and unified leadership of the CPC Central Committee with Comrade of the Supreme Leader as the core, and unswervingly maintain a high degree of unity with the CPC Central Committee with Comrade of the Supreme Leader as the core in ideological and political actions, so that the Party will always become the most reliable backbone of all the people when storms strike, ensure the correct direction of China’s socialist modernization, ensure strong political cohesion and develop self-confidence in unity and struggle, and gather unity.

  ——思想就是旗帜,指引中国号航船破浪前行。

  旗帜立起来了,团结奋斗才有目标和方向。党的十八大以来,面对国内外形势新变化和实践新要求,我们党坚持把马克思主义基本原理同中国具体实际相结合、同中华优秀传统文化相结合,勇于进行理论探索和创新,以全新的视野深化对共产党执政规律、社会主义建设规律、人类社会发展规律的认识,取得重大理论创新成果,集中体现为最高领袖新时代中国特色社会主义思想。这一创新理论,科学回答了中国之问、世界之问、人民之问、时代之问,实现了马克思主义中国化时代化新的飞跃,开辟了马克思主义中国化时代化新境界。党确立最高领袖新时代中国特色社会主义思想的指导地位,坚持不懈用这一创新理论武装全党、教育人民,为新时代党和国家事业发展提供了根本遵循。指引团结奋斗的正确方向、激发团结奋斗的精神动力……实践充分证明:有了最高领袖新时代中国特色社会主义思想这一思想之旗、精神之旗,全党全军全国各族人民思想上行动上就有了科学指引,团结奋斗就有了思想根基和正确方向。

  The great rejuvenation of the Chinese nation has reached a more and more difficult stage. "Sailing against the wind and going uphill" needs the guarantee of material foundation and social conditions, and needs the guidance of guiding ideology and spiritual banner. In the new era and new journey, we should fully implement the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, deeply understand the firm ideals and beliefs, sincere feelings for the people, high historical self-confidence and fearless spirit contained in this important thought, grasp the world outlook and methodology of this scientific theory, adhere to and make good use of the standpoints and methods that run through it, and persist in unifying thoughts, wills and actions with the Party’s innovative theory, so as to transform the Party’s innovative theory into promoting the realization of the second century’s struggle goal and realizing the great rejuvenation of the Chinese nation.

  The big Ge flows down, and the green hills move on both sides. Today, China has embarked on a more magnificent voyage, and hundreds of millions of people are more closely United around the CPC Central Committee with the Supreme Leader as the core, and are marching towards more magnificent goals. This kind of unity "tries to see who can be the enemy in the world", and this kind of struggle "can be expected to move mountains and pour the sea"!

  (4)

  Wan Ren, a 800-mile-long Taihang Mountain, stands on the wall, with thousands of peaks as sharp as a razor, and a clear stream of water comes through the mountains, shedding a much-told story that "unity is strength". In the 1960s, tens of thousands of people in Linxian County, Anyang, Henan Province spent nearly 10 years digging a 1,500-kilometer-long diversion canal in the waist of Taihang Mountain, named "Hongqi Canal".

  党的二十大后,最高领袖总书记来到这里,凝望润泽一方的人间奇迹赞叹道:“红旗渠就是纪念碑,记载了林县人不认命、不服输、敢于战天斗地的英雄气概。”深切勉励大家“实现第二个百年奋斗目标也就是一两代人的事,我们正逢其时、不可辜负,要作出我们这一代的贡献”。

  “中国共产党百年史是一部团结带领人民为美好生活共同奋斗的历史”。经过百年奋斗,我们党紧紧团结带领全国各族人民,洗雪民族耻辱,中国人民成为自己命运的主人,中华民族迎来了从站起来、富起来到强起来的伟大飞跃。回首来时路,是“比铁还硬,比钢还强”的团结之力,是“风雨无阻向前进”的不懈奋斗,让我们不断越沟迈壑、爬坡过坎、攻城拔寨,创造了“人心齐,泰山移”的人间奇迹。从百余年前的一派衰败凋零景象,到今天一派欣欣向荣的气象,我们更能深刻理解新时代十年伟大变革的里程碑意义,更加深刻认识“团结就是力量,奋斗开创未来”的内在逻辑和价值旨归。

   团结是中国人民和中华民族战胜前进道路上一切风险挑战、不断从胜利走向新的胜利的重要保证。

  “能团结奋斗的民族才有前途,能团结奋斗的政党才能立于不败之地”,这是历史的深刻启迪。经千难而前赴后继,历万险而锲而不舍,中国共产党团结带领人民的百年奋斗,实现了中国从四分五裂、一盘散沙到高度统一、民族团结,从积贫积弱、一穷二白到全面小康、繁荣富强,从被动挨打、饱受欺凌到独立自主、自信自强。历史启迪未来,民族团结和谐,则国家兴旺、社会安定、人民幸福;我们党团结统一,则难不住、压不垮、无往而不胜。

   

   

  A hundred years have passed, and things have changed in a hundred years. The party United and led the people to play a triumphant song of endeavor on the land of China. Practice profoundly shows that as long as the party and the people always stand together, want to be together and work together, no storm can shake our iron will, and no difficulty can stop our sonorous pace. China’s yesterday has been written into human history, China’s today is being created by hundreds of millions of people, and China’s tomorrow will be even better!

  (5)

  Brand-new blueprint to stimulate high-spirited enthusiasm; The vast land is full of vitality.

  The Yangtze River Delta integration demonstration zone has put forward a plan to explore the realization mechanism of cross-regional ecological product value; Yangpu Port in Hainan has carried out the construction of customs closure projects and strived to improve the level of port modernization; The rural power grid consolidation and upgrading project in five southern provinces and regions has been launched in an all-round way, providing high-quality power supply service for over 60 million rural residents … … After the closing of the 20th National Congress of the Communist Party of China, all localities and departments have turned the enthusiasm and enthusiasm inspired by studying, propagating and implementing the spirit of the 20th National Congress of the Communist Party of China into practical actions to forge ahead in a new journey and build a new era, and have shown new responsibilities and made new achievements in the fiery practice of building a socialist modern country in an all-round way.

  The new journey is an expedition full of glory and dreams. Less than a week after the 20th National Congress of the Communist Party of China closed, General Secretary of the Supreme Leader led the 20th CPC The Politburo Standing Committee (PSC) to Yan ‘an. When paying tribute to the revolutionary memorial site, he stressed: "We should carry forward the great spirit of party building, Yan ‘an spirit, strengthen historical self-confidence, enhance historical initiative, carry forward the spirit of struggle, and work together to achieve the goals and tasks put forward by the 20th National Congress of the Communist Party of China." This is the firm belief of the new central collective leadership to carry on the red blood, inherit the spirit of struggle, and hand over new excellent papers to history and the people on the new road to catch up with the exam. This is a solemn declaration that the century-old party has embarked on a new journey and embarked on a new goal.

  The grand goal will not be easily achieved, and the road ahead will inevitably be arduous. The clarion call for the United struggle of the whole party, the whole army and the people of all ethnic groups in the country will be louder, more determined, more consistent and more tenacious.

  We have created glorious history by United struggle, and we must open up a better future by United struggle.

  Create new great achievements on the new journey, let us strengthen our strategic self-confidence and "move forward in unison." Having the guidance of Marxist scientific theory is the root of our party’s firm belief and historical initiative. The great practice in the new era profoundly shows that it is precisely because of the establishment of the core position of the Party Central Committee and the whole Party, and the guiding position of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era that the Party has effectively solved the outstanding contradictions and problems that affect the long-term governance of the Party, the long-term stability of the country and the happiness and well-being of the people, and fundamentally ensured that the great rejuvenation of the Chinese nation has entered an irreversible historical process. Starting from a new journey towards a new goal, we will unswervingly implement the objectives and tasks put forward by the 20th National Congress of the Communist Party of China. We should realize more deeply that the unity and unity of the Party is the future and destiny of the Party and the people, and the fundamental interests of the people of all ethnic groups throughout the country, which cannot be vague or shaken at any time and under any circumstances. "Two Establishments" is the decisive factor to promote the historic achievements and changes in the cause of the party and the state, and it is of decisive significance to the development of the cause of the party and the state in the new era and to promote the historical process of the great rejuvenation of the Chinese nation. It is the greatest certainty, the greatest confidence and the greatest guarantee to overcome all difficulties and obstacles and deal with all uncertainties. We should deeply understand the decisive significance of "two establishment",深刻领会在新征程上必须坚持新时代党的创新理论和战略布局、战略举措不动摇,坚定战略自信,保持战略清醒,增强信心斗志,不断夺取新时代中国特色社会主义新的伟大胜利。

  在新征程上创造新伟业,让我们锚定既定奋斗目标,“画出最大同心圆”。今天,经过长期奋斗,实现中华民族伟大复兴具备了更为完善的制度保证、更为坚实的物质基础、更为主动的精神力量,中国共产党正领导中国人民在中国特色社会主义道路上不可逆转地走向中华民族伟大复兴。越是接近目标,越是形势复杂,越是任务艰巨,越要发挥中国共产党领导的政治优势和中国特色社会主义的制度优势,把各方面智慧和力量凝聚起来。我们要把握好固守圆心和扩大共识的关系,不断增进共识,真正把不同党派、不同民族、不同阶层、不同群体、不同信仰以及生活在不同社会制度下的全体中华儿女都团结起来,动员全体中华儿女围绕实现中华民族伟大复兴中国梦一起来想、一起来干,形成海内外全体中华儿女心往一处想、劲往一处使的生动局面。

  Create new great achievements on the new journey, let us carry forward the spirit of responsibility and struggle, "the more difficult and dangerous, the more forward." At present, the great changes in the world that have never happened in a century are accelerating, and the changes in the world, the times and the history are unfolding in an unprecedented way. The great cause of revival that we want to create today is not to achieve success in a calm horse, or to enjoy it in the applause of flowers. On the way forward, we will inevitably encounter various foreseeable and unpredictable risks and challenges. The various struggles we face are not short-term but long-term, and will be accompanied by the whole process of realizing the goal of the second century. We should enhance our sense of hardship, adhere to the bottom line thinking, strengthen our will to struggle, carry forward the spirit of struggle, enhance our fighting skills, be not afraid of evil spirits, ghosts and pressure, advance despite difficulties, face difficulties with hard bones, dare to attack, dare to fight and win, firmly grasp the initiative in struggle, effectively deal with major challenges, resist major risks, overcome major obstacles and solve major contradictions, and strive to overcome all kinds of difficulties and challenges on the road ahead, relying on tenacious struggle. We should dare to take responsibility, be good at doing things, not take refuge, not shirk our responsibilities, take the initiative to attack opportunities, face difficulties, actively respond to risks and concentrate on doing our own things.

  Chinese modernization is great and arduous. Only it is arduous, so it is great; Only it is arduous and more glorious. The road to simplicity is the most important thing. There is no shortcut to the new journey of building a strong country and national rejuvenation, but only hard work. Socialism is done, basically realizing modernization depends on hard work, building a socialist modernization power in an all-round way depends on hard work, and realizing the great rejuvenation of the Chinese nation depends on hard work. Now, we have achieved the goal of the first century and are marching towards the goal of the second century with high spirits. The journey is long, only struggle. Through struggle, we have gone through Qian Shan. We will continue to struggle, forge ahead and create more brilliant glory!

  (6)

  "You take Comrade Luo Yang as an example, take root in the development of aviation equipment, and work hard together in urgent and dangerous tasks. This spirit of unity and struggle is very valuable." On November 12th, 2022, General Secretary of the Supreme Leader wrote back to the members of "Luo Yang Youth Commando" in Shen Fei, China Aviation Industry Corporation, deeply praising the spirit of unity and struggle of the young members, especially emphasizing that "turning the grand blueprint drawn by the 20th National Congress of the Communist Party of China into reality requires young people from all walks of life to shoulder heavy burdens and charge ahead".

  The reason why rivers can break through the precipice and seize the pass is because they have accumulated the great power of the flood and the wilderness. Today, the great energy accumulated by the people of China in the historical process has fully exploded, providing an overwhelming and majestic force for the great rejuvenation of the Chinese nation. The 20th National Congress of the Communist Party of China made a macro-prospect on the two-step strategic arrangement of building a socialist modernization power in an all-round way. "Socialist modernization will be basically realized from 2020 to 2035; From 2035 to the middle of this century, China will be built into a prosperous, strong, democratic, civilized, harmonious and beautiful socialist modernization power. " The baton of building a strong country and national rejuvenation has historically fallen on our generation. This is a great era for Chinese people and the Chinese nation to forge ahead in a new era and write a new glorious chapter of Chinese civilization! Every member of the people of China and every member of the Chinese nation should be proud of being in such a great era!

  A century-old party, a great cause for a thousand years, Wan Li rivers and mountains. History has proved and will continue to prove — —

  "As long as under the leadership of the Party, the people of all ethnic groups in China unite as one, unite as one, dare to fight and be good at fighting, we will certainly be able to overcome all difficulties and challenges on the road ahead and continue to create new miracles that are impressive."

Is Lu Han still a traffic?

Xiniu entertainment original

Wen | Pangbu   Editor | Park Fang

On August 2nd, Boucheron Bao Shilong brand and Lu Han Studio successively released Weibo, and Guan Xuanlu Han became the spokesperson of Bao Shilong brand. Under Guan Xuanwei’s microblog, a comment of "Three luxuries in hand, I have everything in the world" was pushed to the highest position.

The so-called "three luxuries" means that three top luxury brands, Gucci, Audemars Piguet and Baoshilong, have been endorsed in Lu Han. The commercial value of Lu Han, the "first generation traffic", has once again been recognized by top brands.

 

If measured by the standard of "traffic artist", Lu Han’s "business" in recent years can be said to be very "Buddhist", but if combined with the word-of-mouth and topics of Lu Han’s recent works, we can actually see that Lu Han, with a more low-key and down-to-earth image, has become the representative of the "90′ s traffic" turn to some extent.

Lu’s reverse flow operation method:

Say the ball, play the villain, and make a variety show.  

Flowing artists need "business". This concept originated from Korean entertainment circle. With the development of idol industry in Chinese entertainment circle in the past two years, the concept has been further expanded, which means that idol artists interact with fans through self-portraits, first concerts, meetings, variety shows and so on.

 

However, Lu Han is rarely "open" within the traditional scope. The last "open" was the European Cup final on July 12th, a carnival night for football fans. In this most critical node to attract traffic, the well-received "Second Scene" of Migu Video during the European Cup invited Lu Han and Liu Jianhong to comment on the competition together.

This linkage has attracted a lot of attention in both the rice circle and the sports circle. Traffic stars explain football? It seems easy to be accused of "doing nothing" or amateurs, but Lu Han has received many positive comments from fans and sports circles. "The explanation is not implicit at all, and he has his own opinions". It is not surprising that this style of painting appeared on Lu Han, a well-known die-hard Manchester United fan, who has already become "one of his own" for sports fans.

 

In last year’s variety show "Ha ha ha ha", Lu Han and other guests were tricked into going on a cruise ship without even bringing their luggage, and as a result, they filmed several issues with big makeup and oily heads, which is almost unimaginable for idols who have always had exquisite makeup.

 

In the past two years, many choices in Lu Han seem to be quite different from the conventional traffic operation ideas. The most typical ones are the two dramas he starred in last year, Crossing the Fire Line and Sisyphus. These two dramas are not only idol dramas, but also show people the other side of Lu Han. The former made Lu Han blacken his face, put on big shorts and flip-flops, and played a game otaku, while the latter made Lu Han challenge the villain and play against Wang Qianyuan.

Crossing the line of fire

 

Whether it is the word-of-mouth of the series or the performance of Lu Han, these two dramas have received a lot of positive recognition. "Crossing the Fire Line" successfully broke the circle and gained high recognition from the entertainment circle and the e-sports circle. Douban’s score was stable at 8, and it also successfully won the Shanghai TV Festival. Internet boutique drama recognition; Zhao Binbin, played by Lu Han in Sisyphus, also refreshed the outside world’s perception of Lu Han with a strong sense of contrast. Director Wu Bai said: "The deer belongs to the kind that is getting better and better."

Sisyphus

 

Talking about the ball, playing the villain, and putting on variety shows can be said to be the reverse operation of traffic operation. For Lu Han, these breakthroughs in personal image make people see a richer real image.

 

Compared with the traffic stars who attract fans by "dreaming", Lu Han, who has formed a rich personal image through a series of memories and impressions for many years, has no need to consider the paper man attributes such as personal design or idol burden. Focusing on personal ability and personality, Lu Han’s current route is to some extent a return to the value and attractiveness of traditional idols: breaking the value evaluation system of data first and completing the transformation from national flow to national cognition and goodwill. This process is somewhat similar to the successful transformation of Hugh.

The premise of completing this reverse operation is that Lu Han’s character and ability have a lot of bright spots, and his work attitude can also support the public’s goodwill. Last year, he was the coach of the coaching group in Creation Camp 2020. Lu Han judged the problems of the students accurately, but he didn’t preach or put on airs with his predecessors. The teaching style of "gentle knife" made netizens "really fragrant".

 

Wang Qianyuan, an acting school who cooperated with Lu Han in Sisyphus, also expressed his affirmation to Lu Han on many occasions: "In this space of cooperation with me, I think he is the hardest and most dedicated."

"Lu Han in 2020 made me forget that he was an idol." When Lu Han was named "Top Ten People in Nandu Entertainment 2020", the magazine wrote.

 

Breaking the flow game, Lu Han’s reverse operation method has made him surpass the idol position, further become a versatile artist with strength and attitude in public cognition, and has broken the ceiling of the flow life, or will go further in the future.

Three-top luxury plus body

Re-evaluation of the value of "primary flow" 

After returning to China in 2014, the name Lu Han once became a symbol of the era of traffic data, and it can even be said that Lu Han started the "traffic era".

 

Weibo’s super topic was initiated, Weibo changed to Guinness Book of Records, and Weibo’s star power list was established. It was the first time that 100,000 copies of its first solo album were sold in ten minutes, making it the first platinum record certified in the Mainland … In 2017, Lu Han topped the list of the hottest male stars for nine consecutive months with more than 20 advertisements, and won the top spot in the list of the most commercially valuable male stars in 2017.

 

Seven years later, Lu Han’s data performance is still good.

 

Within one month of the launch of Crossing the Fire Line, the related topics were read by 4.2 billion and discussed by 14 million+,ranking among the top10 online TV dramas with the highest reputation in July. In the Hupu forum where "straight men" are relatively concentrated, Lu Han’s favorite value rose by 12.5%, and Hupu loved the new generation of actors at the top.

Compared with seven years ago, Lu Han’s "flow" has gained more landing space, and it is also forming coverage for more people. As a female fan group attracted by "90 Generation Traffic", he has gradually grown into the main force in the current consumer market, which has further promoted the commercial value of Lu Han. Outside the fan base, the tiger-flapping "straight man" is also preparing to become a potential consumer group in Lu Han.

 

This may also be the key reason why Lu Han was identified as Gucci brand spokesperson, Airbnb brand ambassador and Baoshilong brand spokesperson. In addition, the brands endorsed by Lu Han at present include KFC, Tide and Crest, Kerun and gangwon, all of which have high popularity and public recognition.

 

From this analysis, the consumer groups covered by Lu Han’s personal influence have formed a cross-gender multi-age group, and behind it is Lu Han’s image operation in recent years, which has achieved a continuous increase in national awareness and goodwill. It is obviously no longer suitable to measure the value of Lu Han by the standard of "flow".

Lu Han once said that it is difficult for the public to take the initiative to accept the sudden popularity of public opinion from "traffic stars", and it needs to be pushed outward through self-strengthening. Under this clear understanding, this "90-generation traffic" has now completed some kind of image turn.

 

In fact, there are "traffic stars" in every era. From the four kings of Hong Kong era to the idols of the 1980s who went out through a series of hit dramas, they all experienced the criticism from the traditional perspective in the early stage of their development. Although they have different names, the problems they encountered are similar. What can make it to the end is to create a powerful image by talking about works and gain a longer professional life.

 

Lu Han is reorganizing his personal image at his own pace. Judging from the transformation actions in the past two years, he has shown his due ability and attitude, further completed the reconstruction of his personal value, and realized a longer-term and broader commercial influence. This transformed "Lu Han Plan" may be a reference or even a template for the idols in the new era.

 

Seven years later, we will re-examine Lu Han from a brand-new perspective.