Huaxi Hospital Translational Medicine Complex opened! Will greatly shorten the time from research to clinical transformation.

Cover journalist Ning Zhi
On July 18th, the comprehensive building of translational medicine in Huaxi Hospital, the core base of clinical research in the national major scientific and technological infrastructure of translational medicine (Sichuan), was officially opened.
The reporter learned from the scene that there are currently five national-level facilities for translational medicine in China, and the national major scientific and technological infrastructure for translational medicine (Sichuan) is the second national-level facility for translational medicine after Shanghai, and it is also the first national major scientific and technological infrastructure for biotherapy translational medicine.
Journalist visit
How tall is the translational medicine complex?
In the emergency building of west china hospital, through a corridor, you come to the comprehensive building of translational medicine in Huaxi Hospital. The building is divided into two floors underground and 16 floors above ground, with nearly 200 research beds.
On the morning of the 18th, the reporter first came to the laminar flow research ward on the 16th floor of the translational medicine complex of Huaxi Hospital, where there were all kinds of nurses’ stations and treatment rooms, and several patients who had participated in clinical trials were admitted.
The reporter learned that the laminar flow research ward is jointly built and managed by the Department of Hematology and the National Drug Clinical Research Center to carry out clinical research including autologous, blood/non-blood integration. Zhu Jinbing, chief resident physician of laminar flow ward, said that the main feature of laminar flow ward is aseptic management, which filters out germs and other particles in the air through special filtering devices to create a safe environment for patients participating in clinical trials.
Subsequently, the reporter went to the early clinical research ward on the 15th floor, the precision medicine center on the 7th floor, the information center on the 9th floor, etc. Each floor has cutting-edge equipment and a sense of science and technology. For example, a robot can monitor the humidity and temperature of each cabinet at any time; In the intelligent reference room, the staff only need to input the document number, and the equipment can automatically find out the paper document quickly.
Expert interpretation
Help to introduce more domestic innovative drugs.
Li Weimin, Dean of West China Clinical Medical College/West China Hospital of Sichuan University, said that after the comprehensive building of translational medicine in West China Hospital is put into operation, it will significantly enhance the independent innovation ability of translational medicine research in China and shorten the time from basic research to clinical application by 30-50%; In the next 5-10 years, 50-100 candidate biotherapy products will be supported for transformation.
"Huaxi Hospital attaches great importance to original research, basic research and how to turn basic research into clinical application." Li Weimin said that the opening of the comprehensive building of translational medicine in West China Hospital will further promote the transformation of basic research into clinical application. "China’s drugs are mainly generic drugs, and there are fewer original drugs with independent intellectual property rights. In the future, we will be able to produce more domestic original new drugs by transforming the large facilities of the comprehensive medical building. On the other hand, the price of original new drugs may be lower, thus benefiting more people."
Wei Yuquan, academician of China Academy of Sciences, director of west china hospital Clinical Cancer Center and director of the State Key Laboratory of Biotherapy, said that the comprehensive building of translational medicine in West China Hospital will accelerate the transformation of basic research into clinic and industry. "The bottleneck of our current biomedicine is that basic research and clinical transformation are not closely applied. After the establishment of major facilities, it can speed up the transformation and increase the scale of transformation. "
Frequent highlights
It has three sharp tools to lead the national biotherapy transformation.
The National Major Science and Technology Infrastructure of Translational Medicine (Sichuan) is the largest biotherapy translational medicine research center with the highest comprehensive integration, the most advanced equipment and high openness and sharing in China, and it has three sharp tools to lead the biotherapy transformation in China.
First, the accurate imaging and evaluation service chain runs through the whole process of "basic discovery-clinical research-achievement transformation-industrial development".
As an important part of this chain, the precision imaging center is one of the few clinical imaging research centers in the world that integrates first-class equipment such as 7T magnetic resonance, magnetoencephalography and PET-MRI. Have the research and development ability to lead the international advanced technology. In addition, precision medicine center is the core component of clinical detection module of translational medicine facilities, and it is one of the important strategic development directions of Huaxi Hospital. The center has built three top platforms, namely high-throughput sequencing, single cell sequencing and bioinformatics analysis. It has the most complete and advanced second-generation and third-generation sequencing systems of Illumina, Ion Torrent, Huada and Oxford Nanopore series, 10X Genomics single-cell database building system and high-performance server in the world, mainly carrying out scientific research and clinical testing services based on whole genome, whole exon group and gene panel sequencing. It has undertaken the whole genome sequencing task of a cohort study of 100,000 natural people in West China Hospital. The single detection flux can reach 140 people and the data analysis takes 15 minutes per person. Its sequencing and analysis ability is the first in medical institutions in China, and it has more than 1 million sample resources available for sequencing research.
Second, the national drug clinical trial institution (clinical trial center) is an innovative clinical trial research platform with "one-stop" bags.
As an innovative clinical trial research platform with full functional integration, all-round open sharing and one-stop bag-carrying, the national drug clinical trial institution has 21 full-time research doctors with rich clinical and research experience, 187 special research beds and 4 ICU standard rescue wards. The platform integrates the functions of clinical research ward, follow-up center, integrated management of subjects’ research data, clinical examination, endoscopy, imaging and pathology. Intelligent clinical trial system operation, free inspection, green reservation channel, rapid admission process, professional researcher project implementation, the main implementation links of clinical trials can be completed in the Translational Medicine Building in a "one-stop" manner, thus accelerating the implementation of clinical trial projects. In addition to facing the supporting units, the platform is also open to universities, research institutes, enterprises, hospitals and other institutions to realize the whole society.
Third, the large-scale preparation center of biological agents is a "clinical cell preparation factory".
The large-scale preparation center of biological agents is equipped with a number of the most advanced fully automatic and fully closed cell preparation production lines, and the environment of the core area of cell preparation reaches B+A level. According to the latest industry standards and development trends at home and abroad, it is equipped with a large number of advanced cell production, storage and inspection equipment, such as advanced fully automatic cell processing workstations, fully sealed C+ isolators, large-scale cell extraction and purification systems, liquid nitrogen-free refrigeration systems and flow cell sorters, at a cost of 160 million RMB, reaching the domestic leading level. Mainly aimed at the clinical transformation research of cell therapy, it realizes the preparation, quality control and research and development of various immune cells, including CAR-T, NK (natural killer cells) and umbilical cord blood and mesenchymal stem cells. It is a modern, standardized and large-scale "clinical cell preparation factory".
Transformation case
Huaxi Hospital released two major transformation achievements.
At the launching ceremony, west china hospital released two major transformation achievements.
One originated from the team of Academician Wei Yuquan. The recombinant protein COVID-19 vaccine, developed by the team of Academician Wei Yuquan, is based on the precise design of structural biology, targeting the binding site between novel coronavirus and human cells. By using insect cells to multiply in culture medium, the gene of new coronavirus is introduced into insect cells to produce high-quality recombination vaccines protein. At present, the phase III clinic of the vaccine is cooperating with Japan, Nepal, Kenya, Indonesia, Bahrain, Belarus, Uzbekistan, Mexico and other countries.
The other is from Professor Liu Jin’s team. The team obtained the certificate of Class 1.1 new anesthetic drug and the contract fund of 500 million yuan to start the research and development of skeletal muscle relaxation drugs, and won the "Innovation and Transformation Award" in west china hospital in 2021 respectively. Among them, phosphopropofol disodium for injection was successfully approved as the "Drug Registration Certificate" for Class I new drugs, which is the first new drug certificate with independent intellectual property rights obtained by Huaxi Hospital.
Reporting/feedback

Unity and struggle is the only way for Chinese people to create great historical achievements-forge ahead in a new journey and create new great achievements.

  (1)

  "In the face of profound and complex changes in the international and domestic environment, we must be calm, maintain our strength, strive for progress steadily, act positively, unite and dare to struggle." At the two sessions of the National People’s Congress, the General Secretary of the Supreme Leader profoundly expounded the new goals, new situation and new tasks of China’s development, emphasizing: "Only when all the people are thinking in one place, making efforts in one place, helping each other in the same boat, being United in one mind, being brave in struggle and being good at struggle, can they continuously win new and greater victories."

  The grand goal of building a strong country and national rejuvenation is encouraging and inspiring. The 20th National Congress of the Communist Party of China defined the objectives and tasks of the development of the cause of the Party and the country in the new era and new journey, and called on the whole party, the whole army and the people of all nationalities in China to unite and struggle for building a socialist modern country in an all-round way and promoting the great rejuvenation of the Chinese nation in an all-round way. Looking at today’s China, from the ambitious feat of bravely climbing the peak of the world’s science and technology to the concerted efforts to achieve a major decisive victory in epidemic prevention and control, from the rain or shine to create a better life to the unremitting struggle to promote high-quality development … … More than 9.6 million square kilometers of hot land are thriving and full of vitality, and more than 1.4 billion people are high-spirited and tenacious, and they have gathered into a torrent of China’s high spirits and forge ahead in the new era.

  Strength comes from unity, and happiness comes from struggle. General Secretary of the Supreme Leader profoundly pointed out in the Party’s Report to the 20th CPC National Congress that "United struggle is the only way for Chinese people to create great historical achievements". This important conclusion profoundly reveals the important password of why we succeeded in the past and how we can continue to succeed in the future, and profoundly demonstrates the confidence and determination of the century-old party to lead hundreds of millions of people to unswervingly advance the historical process of the great rejuvenation of the Chinese nation.

  Looking back on the century-long struggle, our party united and led the people of China to achieve great victories in the new-democratic revolution, socialist revolution and construction, reform and opening up, and socialist modernization, and ushered in a new era in Socialism with Chinese characteristics. Looking at the road ahead, we know that the great rejuvenation of the Chinese nation can not be achieved easily, and we must be prepared to make more arduous and arduous efforts. Follow the main road to Wan Li. No matter how the situation changes, no matter how severe the challenge is, we must anchor the central task of the Party in the new era and new journey, firmly grasp the requirements of the times of unity and struggle, strengthen historical self-confidence, enhance historical initiative, unite as one, unite as one, strive to achieve the set goals with perseverance, and unremittingly promote the great rejuvenation of the Chinese nation with a sober mind.

  The century-old achievements are brilliant, and the century-old big party is in its prime. The best tribute to the history of a hundred years of struggle is to write a new history of struggle.

  (2)

  This scene is full of tears.

  On February 4, 2022, the opening ceremony of Beijing Winter Olympics was held in the National Stadium. Accompanied by My People,My Country’s melodious melody, all walks of life, advanced model figures and representatives of 56 nationalities in China slowly passed the bright five-star red flag to the flag-raising area of the stadium with their hands. This is a powerful interpretation of the unity spirit of hundreds of millions of people and a beautiful presentation of the struggle figure in the new era.

  History has witnessed magnificent progress, and time has engraved solid steps. Since the 18th National Congress of the Communist Party of China, Socialism with Chinese characteristics has entered a new era. In the face of the complicated situation in which the situation in the past century and the epidemic situation in the century are superimposed and the world has entered a new period of turmoil and change, and faced with risks and challenges that are rare in the world and history, the CPC Central Committee with the Supreme Leader as the core sized up the situation, made bold choices, forged ahead, overcame difficulties, United and led the whole party, the whole army and the people of all ethnic groups across the country to set up their sleeves and go forward, rain or shine, bravely singing the magnificent triumph of "the wind blows the red flag over the mark" and struggling to write.

  It is hard to forget that in the second decade of the 21st century, China’s economic development is facing a complicated situation of "three-phase superposition" of growth rate shift period, structural adjustment pain period and early stimulus policy digestion period. At that time, after the aftermath of the international financial crisis, various voices such as Thucydides Trap and Tacitus appeared one after another, and various arguments such as "China threat theory", "China collapse theory" and "China stagnation theory" were endless. Our party put forward that China’s economic development has entered a new normal, put forward and implemented new development concepts, and led the people to boldly turn back the waves and sail against the wind on the voyage of promoting high-quality development, writing a new chapter in the "two miracles";

  It is hard to forget that poverty alleviation has entered the critical period of decisive battle, and the rest are the most difficult hard bones. Faced with the "additional test questions" that followed one after another, the decisive battle against poverty was tight, demanding and heavy, and the CPC Central Committee organized and launched a massive people’s war against poverty. The Party has led the people to overcome difficulties, carry forward the spirit of nailing, dare to gnaw at hard bones, overcome one poverty after another, win the biggest battle against poverty in human history, and create another miracle in history.

  难以忘记,世纪疫情来势汹汹,人民生命安全和身体健康面临严重威胁。我们党始终坚持人民至上、生命至上,以强烈的历史担当和强大的战略定力,因时因势优化调整防控政策措施,高效统筹疫情防控和经济社会发展。中国共产党团结带领亿万人民同舟共济、同心抗疫,成功避免了致病力较强、致死率较高的病毒株的广泛流行,有效保护了人民群众生命安全和身体健康,创造了人类文明史上人口大国成功走出疫情大流行的奇迹;

  难以忘记,历经7年艰辛努力,北京冬奥会、冬残奥会胜利举办。在全球疫情大流行背景下,党中央领导全党全国人民克服各种困难挑战,全部参与者坚持“一刻也不能停,一步也不能错,一天也误不起”,付出了艰苦卓绝的努力,向世界奉献了一届简约、安全、精彩的奥运盛会,全面兑现了对国际社会的庄严承诺;

  … … … …

  When the sea flows, you will show your true colors as a hero; Ride the wind and waves, and you will know more about top gun. Looking back on the extraordinary and unusual journey of this decade, the General Secretary profoundly pointed out: "The great achievements of the new era are made by the party and the people together!" "Over the years, all kinds of risks and challenges we have faced have come one after another, one after another, and every battle has been won by the United struggle and tenacious struggle of all the people."

  In this decade, the task of reform, development and stability is unprecedented. In the arduous struggle, our party has taken charge of great struggles, great projects, great undertakings and great dreams, promoted the overall layout of the "five in one" as a whole, coordinated the promotion of the "four comprehensive" strategic layout, and United and led hundreds of millions of people to push forward Socialism with Chinese characteristics in the new era with a spirit of hard work. Respect the people’s initiative and promote the reform in important areas and key links; Stimulate the whole society to create vitality and take solid steps to promote high-quality development; Put forward the important exposition of people’s democracy in the whole process, and promote the vitality of Socialism with Chinese characteristics’s democratic politics in the new era; Improve the social governance system of co-construction, co-governance and sharing, and promote the construction of safe China to a higher level … … Ten years of hard work is precisely because the United struggle of the Party and the people has gathered the surging momentum of career development and created the great achievements of Socialism with Chinese characteristics in the new era.

  In this decade, the number of contradictory risks and challenges is unprecedented. Facing the dangers of beach-related, climbing and breaking through customs, we have waged a great struggle with many new historical characteristics. Our party has relied on the people closely to stabilize the economy, promote development, fight poverty, build a well-off society, control epidemics, resist major disasters, cope with emergencies and turn crises into crises, overcome seemingly insurmountable difficulties and obstacles, and created amazing miracles on earth. When the Wuhan Defence War started, the phrase "I am party member, I will go first" condensed the concerted efforts to fight the epidemic; After the earthquake in Luding, Sichuan, the rescue team grasped the rope and climbed across the river, showing a new era of "flying Luding Bridge"; Before the mountain fire in Chongqing, the headlights of thousands of volunteers formed a defense line to intercept the fire, and built a "new Great Wall" … … It is precisely because of the United struggle of the Party and the people that we have forged ahead in the past ten years that we have gathered a powerful force to overcome difficulties, and Socialism with Chinese characteristics’s career ship has broken waves and made unremitting efforts.

   

  In our new era, everyone is both a witness and a participant. Feeling the pulse of the times, listening to the rhythm of history, adding the glory of the times and creating the splendor of history, one conclusion is particularly clear: the historic achievements and changes in the cause of the party and the state depend on the strong leadership of the CPC Central Committee with the supreme leader as the core and on the United struggle of the whole party, the whole army and the people of all ethnic groups throughout the country.

  (3)

  The greatness of the cause lies not only in the brilliance of the achievement, but also in the magnificence of the process.

  "Unity formed around a clear goal of struggle is the strongest unity, and struggle based on close unity is the most powerful struggle." This is an important conclusion of the great achievements of the new era in the past ten years, and it is also a profound inspiration for creating new great achievements on the new journey.

  — — Goals guide the direction and inspire hundreds of millions of people to think in one place.

  Ten years of unremitting struggle, how many ups and downs, how many thrilling, how many determined to move forward. Adhere to "the people’s yearning for a better life is our goal" and constantly enhance the people’s sense of acquisition, happiness and security; It is proposed that the overall goal of comprehensively deepening reform is to "improve and develop the Socialism with Chinese characteristics system, promote the modernization of the national governance system and governance capacity", and promote the reform with all-round efforts, multiple breakthroughs, steady and in-depth progress; It is clear that the overall goal of comprehensively promoting the rule of law is to "build Socialism with Chinese characteristics’s rule of law system and build a socialist country ruled by law", and strive to make the people feel fair and just in every legal system, every law enforcement decision and every judicial case; Clarify the strategic policy of strictly administering the party in an all-round way, put forward the general requirements for party building in the new era, and "build the party into a Marxist ruling party that always walks in the forefront of the times, is sincerely supported by the people, is brave in self-revolution, can withstand all kinds of storms, and is full of vitality", opening up a new realm of self-revolution of the century-old big party; It is clear that the party’s goal of strengthening the army in the new era is to "build a people’s army that listens to the party’s command, can win battles and has a good style of work, and build the people’s army into a world-class army", so as to promote the revolutionary reshaping of the people’s army as a whole, reorganize its luggage and start again … …

  One by one, bearing in mind the grand goal of the initial mission, the key choice of raising the flag again and again, and the long-term strategic planning fully demonstrate the grandeur, foresight and greatness of the Supreme Leader General Secretary as a Marxist politician, thinker and strategist, and point out the way forward for the United struggle of the whole party, the whole army and the people of all ethnic groups throughout the country. It is under the banner of the Party that we March forward in unison, unite with one heart under the Party’s goal, and move forward with confidence under the strong leadership of the Party that we constantly create a new situation in the cause of Socialism with Chinese characteristics.

  General Secretary of the Supreme Leader stressed: "From now until the middle of this century, it is the central task of the whole party and people to build a socialist modern power in an all-round way and promote the great rejuvenation of the Chinese nation in an all-round way." The 20th National Congress of the Communist Party of China drew a grand blueprint for building a socialist modern country in an all-round way and promoting the great rejuvenation of the Chinese nation in an all-round way with Chinese modernization, and set the overall goal of China’s development by 2035 and the main goals and tasks in the next five years, which sounded the clarion call for United struggle on the land of China. In the new era and new journey, as long as we are United as a "hard piece of steel" under the banner of the Party, we will be able to turn the grand blueprint into a beautiful reality step by step by putting the major decision-making arrangements made by the 20th Party Congress into action and seeing results.

  — — The core cohesive force has led more than 1.4 billion people to twist into a rope.

  We are such a big party and such a big country. Only when the Party Central Committee has authority can we firmly unite the whole party, and then closely unite the people of all ethnic groups throughout the country to form an invincible and powerful force. Since the 18th National Congress of the Communist Party of China, the Party Central Committee with the Supreme Leader as the core has made every effort to promote the Party’s political construction, improved various systems for safeguarding the authority of the Party Central Committee and centralizing and unifying leadership, ensured that the whole Party maintains a high degree of consistency with the Party Central Committee in political stance, political direction, political principles and political road, and significantly enhanced the Party’s political leadership, ideological leadership, mass organization and social appeal. It is the common choice, solemn choice and inevitable choice of the history and the people to establish the core position of the Supreme Leader, the comrades of the CPC Central Committee and the whole party, and it is the luck of the party and the country, the people and the Chinese nation. Take a firm direction in flying clouds, be rock-solid in stormy waves, strategize in risk challenges, calmly control all kinds of complicated situations, and effectively deal with all kinds of risk challenges at home and abroad … … Practice has fully proved that with General Secretary of the Supreme Leader at the helm, more than 1.4 billion people in China will have a leader in United struggle.

  "Building a socialist modern country in an all-round way is a great and arduous undertaking with a bright future and a long way to go." The 20th National Congress of the Communist Party of China (CPC) must be prepared to stand the major test of high winds, high waves and even stormy waves, and put forward the major principles that must be firmly grasped, with "upholding and strengthening the overall leadership of the Party" as the first priority. In the new era and new journey, we will more consciously safeguard the core position of the CPC Central Committee, General Secretary of the Supreme Leader, the core position of the whole Party, the authority and centralized and unified leadership of the CPC Central Committee with Comrade of the Supreme Leader as the core, and unswervingly maintain a high degree of unity with the CPC Central Committee with Comrade of the Supreme Leader as the core in ideological and political actions, so that the Party will always become the most reliable backbone of all the people when storms strike, ensure the correct direction of China’s socialist modernization, ensure strong political cohesion and develop self-confidence in unity and struggle, and gather unity.

  ——思想就是旗帜,指引中国号航船破浪前行。

  旗帜立起来了,团结奋斗才有目标和方向。党的十八大以来,面对国内外形势新变化和实践新要求,我们党坚持把马克思主义基本原理同中国具体实际相结合、同中华优秀传统文化相结合,勇于进行理论探索和创新,以全新的视野深化对共产党执政规律、社会主义建设规律、人类社会发展规律的认识,取得重大理论创新成果,集中体现为最高领袖新时代中国特色社会主义思想。这一创新理论,科学回答了中国之问、世界之问、人民之问、时代之问,实现了马克思主义中国化时代化新的飞跃,开辟了马克思主义中国化时代化新境界。党确立最高领袖新时代中国特色社会主义思想的指导地位,坚持不懈用这一创新理论武装全党、教育人民,为新时代党和国家事业发展提供了根本遵循。指引团结奋斗的正确方向、激发团结奋斗的精神动力……实践充分证明:有了最高领袖新时代中国特色社会主义思想这一思想之旗、精神之旗,全党全军全国各族人民思想上行动上就有了科学指引,团结奋斗就有了思想根基和正确方向。

  The great rejuvenation of the Chinese nation has reached a more and more difficult stage. "Sailing against the wind and going uphill" needs the guarantee of material foundation and social conditions, and needs the guidance of guiding ideology and spiritual banner. In the new era and new journey, we should fully implement the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era, deeply understand the firm ideals and beliefs, sincere feelings for the people, high historical self-confidence and fearless spirit contained in this important thought, grasp the world outlook and methodology of this scientific theory, adhere to and make good use of the standpoints and methods that run through it, and persist in unifying thoughts, wills and actions with the Party’s innovative theory, so as to transform the Party’s innovative theory into promoting the realization of the second century’s struggle goal and realizing the great rejuvenation of the Chinese nation.

  The big Ge flows down, and the green hills move on both sides. Today, China has embarked on a more magnificent voyage, and hundreds of millions of people are more closely United around the CPC Central Committee with the Supreme Leader as the core, and are marching towards more magnificent goals. This kind of unity "tries to see who can be the enemy in the world", and this kind of struggle "can be expected to move mountains and pour the sea"!

  (4)

  Wan Ren, a 800-mile-long Taihang Mountain, stands on the wall, with thousands of peaks as sharp as a razor, and a clear stream of water comes through the mountains, shedding a much-told story that "unity is strength". In the 1960s, tens of thousands of people in Linxian County, Anyang, Henan Province spent nearly 10 years digging a 1,500-kilometer-long diversion canal in the waist of Taihang Mountain, named "Hongqi Canal".

  党的二十大后,最高领袖总书记来到这里,凝望润泽一方的人间奇迹赞叹道:“红旗渠就是纪念碑,记载了林县人不认命、不服输、敢于战天斗地的英雄气概。”深切勉励大家“实现第二个百年奋斗目标也就是一两代人的事,我们正逢其时、不可辜负,要作出我们这一代的贡献”。

  “中国共产党百年史是一部团结带领人民为美好生活共同奋斗的历史”。经过百年奋斗,我们党紧紧团结带领全国各族人民,洗雪民族耻辱,中国人民成为自己命运的主人,中华民族迎来了从站起来、富起来到强起来的伟大飞跃。回首来时路,是“比铁还硬,比钢还强”的团结之力,是“风雨无阻向前进”的不懈奋斗,让我们不断越沟迈壑、爬坡过坎、攻城拔寨,创造了“人心齐,泰山移”的人间奇迹。从百余年前的一派衰败凋零景象,到今天一派欣欣向荣的气象,我们更能深刻理解新时代十年伟大变革的里程碑意义,更加深刻认识“团结就是力量,奋斗开创未来”的内在逻辑和价值旨归。

   团结是中国人民和中华民族战胜前进道路上一切风险挑战、不断从胜利走向新的胜利的重要保证。

  “能团结奋斗的民族才有前途,能团结奋斗的政党才能立于不败之地”,这是历史的深刻启迪。经千难而前赴后继,历万险而锲而不舍,中国共产党团结带领人民的百年奋斗,实现了中国从四分五裂、一盘散沙到高度统一、民族团结,从积贫积弱、一穷二白到全面小康、繁荣富强,从被动挨打、饱受欺凌到独立自主、自信自强。历史启迪未来,民族团结和谐,则国家兴旺、社会安定、人民幸福;我们党团结统一,则难不住、压不垮、无往而不胜。

   

   

  A hundred years have passed, and things have changed in a hundred years. The party United and led the people to play a triumphant song of endeavor on the land of China. Practice profoundly shows that as long as the party and the people always stand together, want to be together and work together, no storm can shake our iron will, and no difficulty can stop our sonorous pace. China’s yesterday has been written into human history, China’s today is being created by hundreds of millions of people, and China’s tomorrow will be even better!

  (5)

  Brand-new blueprint to stimulate high-spirited enthusiasm; The vast land is full of vitality.

  The Yangtze River Delta integration demonstration zone has put forward a plan to explore the realization mechanism of cross-regional ecological product value; Yangpu Port in Hainan has carried out the construction of customs closure projects and strived to improve the level of port modernization; The rural power grid consolidation and upgrading project in five southern provinces and regions has been launched in an all-round way, providing high-quality power supply service for over 60 million rural residents … … After the closing of the 20th National Congress of the Communist Party of China, all localities and departments have turned the enthusiasm and enthusiasm inspired by studying, propagating and implementing the spirit of the 20th National Congress of the Communist Party of China into practical actions to forge ahead in a new journey and build a new era, and have shown new responsibilities and made new achievements in the fiery practice of building a socialist modern country in an all-round way.

  The new journey is an expedition full of glory and dreams. Less than a week after the 20th National Congress of the Communist Party of China closed, General Secretary of the Supreme Leader led the 20th CPC The Politburo Standing Committee (PSC) to Yan ‘an. When paying tribute to the revolutionary memorial site, he stressed: "We should carry forward the great spirit of party building, Yan ‘an spirit, strengthen historical self-confidence, enhance historical initiative, carry forward the spirit of struggle, and work together to achieve the goals and tasks put forward by the 20th National Congress of the Communist Party of China." This is the firm belief of the new central collective leadership to carry on the red blood, inherit the spirit of struggle, and hand over new excellent papers to history and the people on the new road to catch up with the exam. This is a solemn declaration that the century-old party has embarked on a new journey and embarked on a new goal.

  The grand goal will not be easily achieved, and the road ahead will inevitably be arduous. The clarion call for the United struggle of the whole party, the whole army and the people of all ethnic groups in the country will be louder, more determined, more consistent and more tenacious.

  We have created glorious history by United struggle, and we must open up a better future by United struggle.

  Create new great achievements on the new journey, let us strengthen our strategic self-confidence and "move forward in unison." Having the guidance of Marxist scientific theory is the root of our party’s firm belief and historical initiative. The great practice in the new era profoundly shows that it is precisely because of the establishment of the core position of the Party Central Committee and the whole Party, and the guiding position of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era that the Party has effectively solved the outstanding contradictions and problems that affect the long-term governance of the Party, the long-term stability of the country and the happiness and well-being of the people, and fundamentally ensured that the great rejuvenation of the Chinese nation has entered an irreversible historical process. Starting from a new journey towards a new goal, we will unswervingly implement the objectives and tasks put forward by the 20th National Congress of the Communist Party of China. We should realize more deeply that the unity and unity of the Party is the future and destiny of the Party and the people, and the fundamental interests of the people of all ethnic groups throughout the country, which cannot be vague or shaken at any time and under any circumstances. "Two Establishments" is the decisive factor to promote the historic achievements and changes in the cause of the party and the state, and it is of decisive significance to the development of the cause of the party and the state in the new era and to promote the historical process of the great rejuvenation of the Chinese nation. It is the greatest certainty, the greatest confidence and the greatest guarantee to overcome all difficulties and obstacles and deal with all uncertainties. We should deeply understand the decisive significance of "two establishment",深刻领会在新征程上必须坚持新时代党的创新理论和战略布局、战略举措不动摇,坚定战略自信,保持战略清醒,增强信心斗志,不断夺取新时代中国特色社会主义新的伟大胜利。

  在新征程上创造新伟业,让我们锚定既定奋斗目标,“画出最大同心圆”。今天,经过长期奋斗,实现中华民族伟大复兴具备了更为完善的制度保证、更为坚实的物质基础、更为主动的精神力量,中国共产党正领导中国人民在中国特色社会主义道路上不可逆转地走向中华民族伟大复兴。越是接近目标,越是形势复杂,越是任务艰巨,越要发挥中国共产党领导的政治优势和中国特色社会主义的制度优势,把各方面智慧和力量凝聚起来。我们要把握好固守圆心和扩大共识的关系,不断增进共识,真正把不同党派、不同民族、不同阶层、不同群体、不同信仰以及生活在不同社会制度下的全体中华儿女都团结起来,动员全体中华儿女围绕实现中华民族伟大复兴中国梦一起来想、一起来干,形成海内外全体中华儿女心往一处想、劲往一处使的生动局面。

  Create new great achievements on the new journey, let us carry forward the spirit of responsibility and struggle, "the more difficult and dangerous, the more forward." At present, the great changes in the world that have never happened in a century are accelerating, and the changes in the world, the times and the history are unfolding in an unprecedented way. The great cause of revival that we want to create today is not to achieve success in a calm horse, or to enjoy it in the applause of flowers. On the way forward, we will inevitably encounter various foreseeable and unpredictable risks and challenges. The various struggles we face are not short-term but long-term, and will be accompanied by the whole process of realizing the goal of the second century. We should enhance our sense of hardship, adhere to the bottom line thinking, strengthen our will to struggle, carry forward the spirit of struggle, enhance our fighting skills, be not afraid of evil spirits, ghosts and pressure, advance despite difficulties, face difficulties with hard bones, dare to attack, dare to fight and win, firmly grasp the initiative in struggle, effectively deal with major challenges, resist major risks, overcome major obstacles and solve major contradictions, and strive to overcome all kinds of difficulties and challenges on the road ahead, relying on tenacious struggle. We should dare to take responsibility, be good at doing things, not take refuge, not shirk our responsibilities, take the initiative to attack opportunities, face difficulties, actively respond to risks and concentrate on doing our own things.

  Chinese modernization is great and arduous. Only it is arduous, so it is great; Only it is arduous and more glorious. The road to simplicity is the most important thing. There is no shortcut to the new journey of building a strong country and national rejuvenation, but only hard work. Socialism is done, basically realizing modernization depends on hard work, building a socialist modernization power in an all-round way depends on hard work, and realizing the great rejuvenation of the Chinese nation depends on hard work. Now, we have achieved the goal of the first century and are marching towards the goal of the second century with high spirits. The journey is long, only struggle. Through struggle, we have gone through Qian Shan. We will continue to struggle, forge ahead and create more brilliant glory!

  (6)

  "You take Comrade Luo Yang as an example, take root in the development of aviation equipment, and work hard together in urgent and dangerous tasks. This spirit of unity and struggle is very valuable." On November 12th, 2022, General Secretary of the Supreme Leader wrote back to the members of "Luo Yang Youth Commando" in Shen Fei, China Aviation Industry Corporation, deeply praising the spirit of unity and struggle of the young members, especially emphasizing that "turning the grand blueprint drawn by the 20th National Congress of the Communist Party of China into reality requires young people from all walks of life to shoulder heavy burdens and charge ahead".

  The reason why rivers can break through the precipice and seize the pass is because they have accumulated the great power of the flood and the wilderness. Today, the great energy accumulated by the people of China in the historical process has fully exploded, providing an overwhelming and majestic force for the great rejuvenation of the Chinese nation. The 20th National Congress of the Communist Party of China made a macro-prospect on the two-step strategic arrangement of building a socialist modernization power in an all-round way. "Socialist modernization will be basically realized from 2020 to 2035; From 2035 to the middle of this century, China will be built into a prosperous, strong, democratic, civilized, harmonious and beautiful socialist modernization power. " The baton of building a strong country and national rejuvenation has historically fallen on our generation. This is a great era for Chinese people and the Chinese nation to forge ahead in a new era and write a new glorious chapter of Chinese civilization! Every member of the people of China and every member of the Chinese nation should be proud of being in such a great era!

  A century-old party, a great cause for a thousand years, Wan Li rivers and mountains. History has proved and will continue to prove — —

  "As long as under the leadership of the Party, the people of all ethnic groups in China unite as one, unite as one, dare to fight and be good at fighting, we will certainly be able to overcome all difficulties and challenges on the road ahead and continue to create new miracles that are impressive."

First batch! Yun Qi’s boundless code fuzzy test system passed the fuzzy test capability evaluation of China Institute of Information and Communication.

Recently, Yun Qi Infinite Code Fuzzy Testing System participated in the standard evaluation of "Fuzzy Testing Architecture Capability Requirements" of China ICT Institute. In order to verify the safety capability of fuzzy test products in a more standard form, the "Capability Requirements of Fuzzy Test Architecture" standardizes the platform capability and engine capability of black-box and gray-box fuzzy tests, including 4 capability domains, 28 capability items and 246 capability indicators, and provides the overall guidance for the capability construction of fuzzy test platforms. According to the comprehensive performance of fuzzy test platform in different capability domains, it is divided into three capability levels: basic level, enhanced level and advanced level.

After the inspection by China Institute of Information and Communication Technology, the Infinite Code Fuzzy Testing System passed the index test of "Fuzzy Testing Architecture Capability Requirements" with the highest score, and its gray box platform capability domain and gray box engine capability domain both reached the "advanced level" requirement of fuzzy testing technology grading capability evaluation, and the product capability was highly recognized.

Software is the soul of a new generation of information technology, the foundation of the development of digital economy, and the key support for the construction of manufacturing power, network power and digital China. At present, the scale benefit of China’s software and information technology service industry is growing rapidly, and the innovation system of software and information technology service industry is basically established, which promotes the rapid development of new technologies, new products, new models and new formats, and accelerates the changes in lifestyle, production methods and social governance. However, with the increase of the total number of software, software quality accidents are still emerging.

As the leader of a new generation of intelligent fuzzy testing, Yun Qi Infinite has been focusing on the research and innovation of fuzzy testing technology since its establishment, and taking this as the core, it has built a series of products and services based on fuzzy testing, and is committed to helping enterprises solve the problem of security vulnerability mining in various scenarios, bringing more perfect and safer product service experience to enterprises.

1. Technological innovation: AIGC enables intelligent fuzzy testing.

The rapid development of GPT model has had a subversive impact on the production paradigm of various industries. As the leader of a new generation of intelligent fuzzy testing, Yun Qi Infinite takes the lead in integrating AIGC mode into products and empowering the software development stage, which has achieved remarkable results in the automatic generation of test cases and the automatic repair of vulnerabilities.

Security vulnerability detection: After AIGC is integrated into intelligent fuzzy testing, the generation process of test samples can be further optimized for specific input types and unknown defects, which greatly improves the quality and generation efficiency of test samples. Moreover, based on coverage guidance and other technologies, applications can be targeted for detection, code boundaries can be deeply explored, and known and unknown threats can be effectively detected.

Security vulnerability repair: Intelligent code fuzzy testing can accurately locate the defective code fragments and reproduce the causes of vulnerabilities. By using AIGC mode, the repaired code can be automatically generated by taking the detection results such as error code fragments as the input of the defect repair model. This method greatly improves the efficiency of defect repair and lowers the technical threshold of defect repair.

Generally speaking, through the deep integration of fuzzy testing and AIGC, Yun Qi Infinite Intelligent Fuzzy Testing Solution has greatly improved its capabilities in automation, testing depth, testing efficiency and defect repair, and opened a new chapter in intelligent security testing.

2. Yun Qi Infinite Product Service Matrix

Infinite code fuzzy test system

Based on intelligent fuzzy testing technology, Yun Qi Infinitus integrates GPT model, and develops and designs the infinite code fuzzy testing system on the basis of mutation algorithm, genetic algorithm, coverage guidance and many other technologies. Infinite code fuzzy testing system can be applied to development, testing, integration and other links, and it can detect the security of source code/binary files. Compared with the automatic security detection method of traditional detection tools, it can not only efficiently mine and detect and analyze "known and unknown" vulnerabilities, but also integrate AIGC mode, which can automatically generate repair schemes and revised security code fragments, greatly reducing the defect repair time and manual repair cost.

At present, independent test mode and CI/CD integration mode are supported.

Compared with traditional security detection tools, the boundless code fuzzy testing system has four advantages:

1) Detection of zero false positives and reproducible vulnerabilities

The testing method based on dynamic execution ensures that all detected defects are locatable, reproducible and verifiable, and the false positive rate approaches zero.

2) The test granularity is finer and the coverage of the scene is more complete.

Intelligent fuzzy testing based on AIGC, relying on AI genetic mutation algorithm and coverage guidance technology in the sample generation stage, can automatically generate massive (billion-level) high-quality test cases, the overall granularity will be finer, there will be more test points, and the location will be more accurate, which significantly improves the test effect and coverage. This scheme can not only be applied to Web application detection, but also be used in detection scenarios with higher test granularity requirements such as protocols, operating systems and databases.

3) Accurate detection of unknown vulnerabilities

By using AIGC to generate various types of distortion test data, the diversity and complexity of Fuzzing test can be increased, and more types of defects and unknown 0-0day vulnerabilities can be found. For example, by generating a string containing special characters or embedded commands, you can test the fault tolerance and security of the program for different input data.

4) Greatly reduce the cost of bug repair.

By combining AIGC with fuzzy testing, we can generate vulnerability repair suggestions faster and further improve the efficiency of vulnerability repair. Moreover, fuzzy testing with AIGC can realize the closed loop of the whole process of automatic vulnerability mining and repair, greatly improve the work efficiency of testers, and thus save the repair cost.

Infinite Protocol Fuzzy Test System

Infinite protocol fuzzy test system is a black-box protocol fuzzy test system independently developed by Yun Qi Infinite. By providing unexpected input to the target and monitoring abnormal results, it can automatically detect system defects and verify the protocol function, and help enterprises realize automatic security detection from the source, thus improving the security and robustness of protocol application.

The advantages of accurate, intelligent and non-invasive products are as follows:

1) Rich protocol support

Covers nearly 100 mainstream network protocols and supports the creation of custom protocol models;

2) Fully automatic safety inspection

Test cases are automatically generated, test strategies are automatically optimized, and detected vulnerabilities are automatically verified;

3) unknown problems, defense in advance

Massive variation test cases, support the detection of known vulnerabilities, and be good at discovering unknown vulnerabilities;

4) Rich test reports

Provide accurate reports, including key information such as fault classification, repair suggestions and vulnerability details;

5) Eliminate false alarm noise in detection.

Simulate the real running environment of the program to ensure that all detected defects can be reproduced and 0 false positives;

6) Non-invasive

Black-box detection method is adopted, which does not invade the system or engineering code and finds deep loopholes;

Flawless software defect analysis system

Innocent software defect analysis system is a self-developed static source code analysis tool. Combining deep software analysis method and deep learning method, it can detect a large number of deep security vulnerabilities that existing software security testing tools cannot detect, and effectively eliminate a large number of false positives.

1) The detection accuracy is "more accurate"

Intelligent learning automatically eliminates false positives, and the false positive rate is only 1/3 of other products.

2) The detection speed is "faster"

The program analysis engine with independent patent technology and a variety of innovative static analysis technologies shorten the detection time by 1/3.

3) The detection depth is "deeper"

Support cross-file, cross-class and cross-function defect/vulnerability detection of tens of millions of lines of code.

4) Detect vulnerabilities "more"

Can find more known/unknown deep security vulnerabilities.

Dust-free software component analysis system

An all-round intelligent software component analysis platform is built based on the concept of "security moving to the left" and DevSCAOps. The platform has four core component analysis engines: source code, component dependency, binary and container mirroring, which can quickly and accurately identify the third-party open source components used in the software, and then identify the potential security vulnerabilities and license information in the software through the correlation analysis technology, comprehensively judge the related risks, and give suggestions on how to repair the related risks, and rely on the SBOM account management ability to empower enterprises to make internal software.

The platform aims to empower enterprises with the ability of open source security and compliance governance, help enterprises achieve the knowability and controllability of software products in the practical sense, and escort enterprise network security.

Compared with the traditional SCA products, the clean software component analysis system can detect various types of targets, support file-level vulnerability homology analysis, support code autonomy analysis of Xinchuang software, and update data at high frequency, and provide standard SBOM list generation and management functions to effectively support users’ business needs.

1) Software component analysis, which supports source code, component dependency, binary file and container mirroring at the same time.

2) Vulnerability analysis, which supports component vulnerability correlation analysis and file-level vulnerability homology analysis.

3) License compliance analysis, while supporting component risk, conflict risk and tampering risk.

4) Support code copyright compliance analysis

5) Support code autonomy analysis

6)DevOps tool chain support

7) Data update frequency is daily update.

8) Software asset management, which supports the generation and management of SBOM list in international standard SPDX format.

Intelligent fuzzy test service

Relying on the service team’s accumulated experience in the security industry for more than ten years, Yun Qi Infinite has brought innovative intelligent fuzzy testing services to enterprises, including Internet of Things /IOT security testing services, vehicle equipment/vehicle networking security testing, service component security testing and directional vulnerability mining services, which help enterprises to build a more perfect security line and provide more comprehensive security solutions.

The advantages of fuzzy test service include the following:

1) Multi-field professional services: Yun Qi Infinite’s professional teams in the fields of network security, Internet of Things /IoT, cloud computing, big data and blockchain provide customers with high-quality technical services.

2) Rich expert experience: With rich practical experience, Yun Qi’s boundless expert team can quickly understand and locate customers’ core needs, reduce communication costs, and provide customized solutions for customers.

3) Advanced technical means: Yun Qi’s boundless security experts have won many awards in the top international information security competitions, and presented topics in world-renowned public meetings for many times, and their technical level is at the cutting edge in the industry.

4) Strict quality control: Yun Qi Infinite Security Service has established a perfect quality control system, with a complete quality control scheme from project start-up, demand analysis, development, delivery and maintenance, and the project manager will follow up all the way to ensure that every project of customers can be completed on time, with high quality and high standard.

As an advanced method of vulnerability mining and stability detection, the exploration of fuzzy testing technology continues. Next, Yun Qi Infinite will continue to deepen the fuzzy testing technology, build a more perfect product service matrix, and devote itself to the improvement of software development safety and software quality, provide customers with solutions that meet industry standards and use scenarios, and jointly promote the technical concept of system stability represented by fuzzy testing to fill the gap between technical theory and practice.

About the infinity of Yun Qi

Yun Qi Infinite is a new generation of AI-enabled software supply chain security practitioner, who is committed to promoting intelligent security detection and automatic defect repair of AI-enabled information systems. The team has gathered innovative talents in the security field from well-known universities such as Tsinghua and Beihou University, as well as head IT companies such as Huawei and Tencent. It has world-class automatic vulnerability detection and mining capabilities, and its products cover intelligent fuzzy testing, source code defect analysis, software component analysis, and intelligent security knowledge base.

Yun Qi Infinite has obtained dozens of software copyrights and patents, passed ISO 9001, ISO 20000, ISO 27001 and other certifications, participated in the formulation of more than 20 national and industrial standards, and served many industries such as energy, finance, communication and automobile. Since its establishment, the company has completed several rounds of tens of millions of financing.

Disclaimer: This article is reprinted by our website, aiming to provide readers with more news information. The contents involved do not constitute investment and consumption suggestions, and are for readers’ reference only.

[Editor: Zhong Jingwen]