Huaxi Hospital Translational Medicine Complex opened! Will greatly shorten the time from research to clinical transformation.

Cover journalist Ning Zhi
On July 18th, the comprehensive building of translational medicine in Huaxi Hospital, the core base of clinical research in the national major scientific and technological infrastructure of translational medicine (Sichuan), was officially opened.
The reporter learned from the scene that there are currently five national-level facilities for translational medicine in China, and the national major scientific and technological infrastructure for translational medicine (Sichuan) is the second national-level facility for translational medicine after Shanghai, and it is also the first national major scientific and technological infrastructure for biotherapy translational medicine.
Journalist visit
How tall is the translational medicine complex?
In the emergency building of west china hospital, through a corridor, you come to the comprehensive building of translational medicine in Huaxi Hospital. The building is divided into two floors underground and 16 floors above ground, with nearly 200 research beds.
On the morning of the 18th, the reporter first came to the laminar flow research ward on the 16th floor of the translational medicine complex of Huaxi Hospital, where there were all kinds of nurses’ stations and treatment rooms, and several patients who had participated in clinical trials were admitted.
The reporter learned that the laminar flow research ward is jointly built and managed by the Department of Hematology and the National Drug Clinical Research Center to carry out clinical research including autologous, blood/non-blood integration. Zhu Jinbing, chief resident physician of laminar flow ward, said that the main feature of laminar flow ward is aseptic management, which filters out germs and other particles in the air through special filtering devices to create a safe environment for patients participating in clinical trials.
Subsequently, the reporter went to the early clinical research ward on the 15th floor, the precision medicine center on the 7th floor, the information center on the 9th floor, etc. Each floor has cutting-edge equipment and a sense of science and technology. For example, a robot can monitor the humidity and temperature of each cabinet at any time; In the intelligent reference room, the staff only need to input the document number, and the equipment can automatically find out the paper document quickly.
Expert interpretation
Help to introduce more domestic innovative drugs.
Li Weimin, Dean of West China Clinical Medical College/West China Hospital of Sichuan University, said that after the comprehensive building of translational medicine in West China Hospital is put into operation, it will significantly enhance the independent innovation ability of translational medicine research in China and shorten the time from basic research to clinical application by 30-50%; In the next 5-10 years, 50-100 candidate biotherapy products will be supported for transformation.
"Huaxi Hospital attaches great importance to original research, basic research and how to turn basic research into clinical application." Li Weimin said that the opening of the comprehensive building of translational medicine in West China Hospital will further promote the transformation of basic research into clinical application. "China’s drugs are mainly generic drugs, and there are fewer original drugs with independent intellectual property rights. In the future, we will be able to produce more domestic original new drugs by transforming the large facilities of the comprehensive medical building. On the other hand, the price of original new drugs may be lower, thus benefiting more people."
Wei Yuquan, academician of China Academy of Sciences, director of west china hospital Clinical Cancer Center and director of the State Key Laboratory of Biotherapy, said that the comprehensive building of translational medicine in West China Hospital will accelerate the transformation of basic research into clinic and industry. "The bottleneck of our current biomedicine is that basic research and clinical transformation are not closely applied. After the establishment of major facilities, it can speed up the transformation and increase the scale of transformation. "
Frequent highlights
It has three sharp tools to lead the national biotherapy transformation.
The National Major Science and Technology Infrastructure of Translational Medicine (Sichuan) is the largest biotherapy translational medicine research center with the highest comprehensive integration, the most advanced equipment and high openness and sharing in China, and it has three sharp tools to lead the biotherapy transformation in China.
First, the accurate imaging and evaluation service chain runs through the whole process of "basic discovery-clinical research-achievement transformation-industrial development".
As an important part of this chain, the precision imaging center is one of the few clinical imaging research centers in the world that integrates first-class equipment such as 7T magnetic resonance, magnetoencephalography and PET-MRI. Have the research and development ability to lead the international advanced technology. In addition, precision medicine center is the core component of clinical detection module of translational medicine facilities, and it is one of the important strategic development directions of Huaxi Hospital. The center has built three top platforms, namely high-throughput sequencing, single cell sequencing and bioinformatics analysis. It has the most complete and advanced second-generation and third-generation sequencing systems of Illumina, Ion Torrent, Huada and Oxford Nanopore series, 10X Genomics single-cell database building system and high-performance server in the world, mainly carrying out scientific research and clinical testing services based on whole genome, whole exon group and gene panel sequencing. It has undertaken the whole genome sequencing task of a cohort study of 100,000 natural people in West China Hospital. The single detection flux can reach 140 people and the data analysis takes 15 minutes per person. Its sequencing and analysis ability is the first in medical institutions in China, and it has more than 1 million sample resources available for sequencing research.
Second, the national drug clinical trial institution (clinical trial center) is an innovative clinical trial research platform with "one-stop" bags.
As an innovative clinical trial research platform with full functional integration, all-round open sharing and one-stop bag-carrying, the national drug clinical trial institution has 21 full-time research doctors with rich clinical and research experience, 187 special research beds and 4 ICU standard rescue wards. The platform integrates the functions of clinical research ward, follow-up center, integrated management of subjects’ research data, clinical examination, endoscopy, imaging and pathology. Intelligent clinical trial system operation, free inspection, green reservation channel, rapid admission process, professional researcher project implementation, the main implementation links of clinical trials can be completed in the Translational Medicine Building in a "one-stop" manner, thus accelerating the implementation of clinical trial projects. In addition to facing the supporting units, the platform is also open to universities, research institutes, enterprises, hospitals and other institutions to realize the whole society.
Third, the large-scale preparation center of biological agents is a "clinical cell preparation factory".
The large-scale preparation center of biological agents is equipped with a number of the most advanced fully automatic and fully closed cell preparation production lines, and the environment of the core area of cell preparation reaches B+A level. According to the latest industry standards and development trends at home and abroad, it is equipped with a large number of advanced cell production, storage and inspection equipment, such as advanced fully automatic cell processing workstations, fully sealed C+ isolators, large-scale cell extraction and purification systems, liquid nitrogen-free refrigeration systems and flow cell sorters, at a cost of 160 million RMB, reaching the domestic leading level. Mainly aimed at the clinical transformation research of cell therapy, it realizes the preparation, quality control and research and development of various immune cells, including CAR-T, NK (natural killer cells) and umbilical cord blood and mesenchymal stem cells. It is a modern, standardized and large-scale "clinical cell preparation factory".
Transformation case
Huaxi Hospital released two major transformation achievements.
At the launching ceremony, west china hospital released two major transformation achievements.
One originated from the team of Academician Wei Yuquan. The recombinant protein COVID-19 vaccine, developed by the team of Academician Wei Yuquan, is based on the precise design of structural biology, targeting the binding site between novel coronavirus and human cells. By using insect cells to multiply in culture medium, the gene of new coronavirus is introduced into insect cells to produce high-quality recombination vaccines protein. At present, the phase III clinic of the vaccine is cooperating with Japan, Nepal, Kenya, Indonesia, Bahrain, Belarus, Uzbekistan, Mexico and other countries.
The other is from Professor Liu Jin’s team. The team obtained the certificate of Class 1.1 new anesthetic drug and the contract fund of 500 million yuan to start the research and development of skeletal muscle relaxation drugs, and won the "Innovation and Transformation Award" in west china hospital in 2021 respectively. Among them, phosphopropofol disodium for injection was successfully approved as the "Drug Registration Certificate" for Class I new drugs, which is the first new drug certificate with independent intellectual property rights obtained by Huaxi Hospital.
Reporting/feedback

Traveling by train on Beijing Railway, and expanding the new tourism market hand in hand with cultural tourism.

 

  In recent years, with the improvement of railway lines and the improvement of service level, railway transportation has become the first choice for more and more people to travel. Under the background of in-depth integration of culture and tourism, the addition of special tourist trains is not only an important measure to facilitate the people and benefit the people, but also a good opportunity to promote regional economic development and build cultural and tourism brands. Recently, with the holding of a cultural activity, the reporter took a special train to the suburbs of Beijing and started a fresh journey and experience — —

  At 6: 50 on July 15th, with the S501 train of Huairou-Miyun line on the outskirts of Beijing slowly leaving Huangtudian Station, the high-rise buildings in the city gradually faded out of tourists’ sight, and low bungalows and construction sites to be built came into view, followed by parks, green spaces and vegetable greenhouses that made people feel comfortable. Later, the scenery of the city almost disappeared, only patches of corn fields, lush mountains and farmers’ houses in the suburbs of Beijing were sitting in the car, and the whole people followed the scenery outside the car window.

  On this day, with the support of Beijing Municipal Bureau of Culture and Tourism, China Railway Travel Group, a subsidiary of China Railway Beijing Bureau Group Co., Ltd. (hereinafter referred to as "Beijing Railway Bureau"), joined forces with Beijing Urban Railway Investment and Development Co., Ltd., Railway 12306, Gubei Water Town, Jinshanling Great Wall, Yuetu Travel and other units to jointly launch "Slow Crossing the Flower Sea and Pearl Chain Ancient Town — — The series of activities of "Traveling in Beijing by Train" was officially launched to further develop the tourism resources in Miyun District and Huairou District and better meet the needs of people traveling by train. On the same day, the reporter also followed the activity and boarded the S501 tourist train bound for the suburbs of Beijing.

  Comfortable feeling: you can see the green hills and smell the flowers.

  Beijing suburban railway Huaimi Line (S5 line) is a suburban railway connecting the central city of Beijing with Changping District, Huairou District and Miyun District. Its starting station is Huangtudian Station, which is adjacent to Beijing Metro Huoying Station. At present, there are 6 stations on Huaimi Line, including Huangtudian, Changping North, Fangezhuang, Huairou North, Heishan Temple and Gubeikou, with a total length of 135.6 kilometers and the shortest running time of 135 minutes. Compared with last year, this year, when we look at the S501 train with a new look, many old passengers will not recognize it: posters of pink flowers are all over the car body, and seven carriages with four themes, such as "Flowers and Stars", "Coming to the Ancient Town", "Great Great Wall" and "Spiritual Heritage", have their own characteristics. The 1.5-meter-long and 1.2-meter-wide window has a wide view and panoramic view.

  According to Chen Lele, the train conductor, Huaimi Line was officially opened on December 31st, 2017. On April 30th this year, the line was extended to Gubeikou Station in Miyun District, and it was continuously upgraded, which not only reflected the tourism characteristics along the way in the appearance of the train and the layout of the carriages, but also added first-class and second-class seats, and was equipped with a dining car. The one-way fare of this line from the departure station to the terminal station was more attractive, as long as 12 yuan. Look carefully at the route of the S501 train, passing through Yanqi Lake, Hongluo Temple, Qinglong Gorge, Mutianyu Great Wall, Yunmeng Mountain, Heilongtan, Gubei Water Town, Jinshanling Great Wall, Mangshan National Forest Park and many other scenic spots. It is not surprising that it is called "the second train to spring".

  In Beijing, the first "train to spring" which is famous earlier than S5 line is S2 line from Huangtudian to Yanqing District, and the train goes directly to Badaling Scenic Area, which is convenient and fast. Especially when peach blossoms bloom every spring, the scenery along the line is beautiful. This summer coincides with the 2019 Beijing World Horticultural Exposition held in Yanqing District, and the S2 line has sent 75,900 passengers.

  "It’s so convenient to travel now. I arrived at Dazhongsi subway station by bus in the morning, changed to Huoying station, walked out of the station for a few minutes and took the suburban railway. At 9: 10 in the morning, I arrived at Gubeikou, more than 100 kilometers away, and public transportation was seamlessly connected." On the S501 train, the reporter saw that Li Suli, a national model worker and an "old bus", also came to join in. She was delighted with the new changes in railway traffic in the past two years.

  Railway+Cultural Travel: New Ideas and New Choices

  When traveling by train, tourists can usually only sit in a chair and stare blankly out of the window, and travel by car for 10 hours and 10 minutes … … But the S501 train is not so quiet. Less than half an hour after the train left the station, there was a broadcast in the carriage: "Please watch it. Actors from Beijing Group Art Museum will perform several excellent programs for passengers. When they arrive at Huairou and Miyun related sites, local literary and art workers will also get on the bus one after another to bring you special performances."

  Opera "Ode to the Pear Flower", poetry recitation "Reading China", Allegro "New Song of Barracks" … … The programs were staged one after another, and the atmosphere in the carriage was high. Even the conductor Di Boguang sang several songs at the top of his voice, attracting passengers to applaud. Shi Jing, a Beijing citizen who has never seen such a scene on the train, and his son walked and watched excitedly in different carriages and found that the theme and program of each carriage were different. "I originally thought that I could easily see a lot of scenery along the way when I came out to play by train. I didn’t expect that not only there were beautiful natural scenery outside the window, but also the window was as lively as a festival." Shi Jing said.

  "In the past two years, there have been more and more people traveling in Huairou. Many fellow villagers have opened restaurants and built homestays to earn money by tourist reception. Now with this train, it will definitely bring more popularity to Huairou. " The actor permission of Yanqi Lake Art Troupe in Huairou District said happily. Another highlight of this route is the direct access to Gubeishui Town in Miyun District, which is another way to visit the Great Wall and the ancient town after self-driving and bus.

  Ma Wen, deputy inspector of the Beijing Municipal Bureau of Culture and Tourism, said that after this attempt, the idea of cultural and tourism integration was further broadened. In the future, more excellent cultural programs, especially those with regional characteristics and cultural connotations along the train, can be tried to bring to the train, so that tourists can feel the experience of "traveling is traveling" and "traveling in Beijing by train". It can be said that the opening and operation of each tourist route will bring about the upgrading and development of the service industry in the areas along the route, which is a considerable consumer market, and local scenic spots, hotels, transportation and other tourism-related ancillary industries will benefit from it.

  Discovery and observation: the market space needs to be further broadened.

  The opening of a series of special tourist trains reflects people’s yearning for a better life. It is reported that in July and August of 2018 alone, China Railway Corporation organized 200 through-train tourist trains, and incorporated service elements such as hotels, bars, book bars and restaurants into the trains. The highly recognizable trains such as Wudang Mountain, Dunhuang and Panda Train are like flowing cultural business cards, attracting people to set off far away.

  The introduction of special tourist trains has also created a huge tourist market. This time, Beijing Railway Bureau launched the "Railway Smart Tourism Cloud Platform" at the same time. By downloading the "Railway Travel" APP or the "Railway Travel" WeChat applet, tourists can realize the online purchase of tourism products, enjoy the convenient travel with "one-code access, one-click departure and one-price all-inclusive" and the customized service of "railway+traffic connection+scenic spot tickets+individual needs".

  Comfort and freedom from traffic jams are the main reasons why many passengers choose to travel by train. At the same time, for S5 line, some passengers also put forward many suggestions, such as more meals on the bus, more flexible departure time, and further improving the traffic connection conditions to the scenic spot. On the last few kilometers between the station and the scenic spot, a communication mechanism has been established between the train and the scenic spot. When driving to Heishan Temple Station, the previous stop of Gubeikou Station, the flight attendants will contact the station and inform the number of passengers arriving at the destination, and the scenic spot will send a corresponding number of shuttle buses to dock according to the number of tourists. For the problem that some tourists mentioned that the train started too early, the reporter learned that the railway department has also made corresponding adjustments. From August 1 ST, the train was distributed from 6: 50 am to 7: 25 am, and the second train was issued at 2: 27 pm. At the same time, passengers in Huairou and Miyun can also take the bus to the urban area in the morning and afternoon.

  In the reporter’s opinion, the opening of the tourist train is one of the products of the further integration of culture and tourism, and the extensive supply is difficult to meet the escalating travel needs of the people. At present, the operation of tourist special trains in some areas still has the embarrassment of large passenger flow on holidays and "carrying chairs" on weekdays; On the other hand, how to integrate passengers before, during and after the trip to maximize social and economic benefits still needs the cooperation of many departments to solve the crux. (China Culture News reporter Li Xue)

"Little Joy" is not happy. "Everything is fine" is quite bad. Is it a "title party"?

"Little Joy" stills

  "Little Joy" ended, and Douban scored a high score of 8.3. This is a realistic drama focusing on the college entrance examination, family and parent-child relationship. The audience can’t stop watching it, but they are also worried. Even many people are abused to be angry: breaking up, unemployment, depression, depression, and jumping into the sea and getting cancer! What’s so funny about this play? Some netizens ridiculed that "Little Joy" should be renamed "Old Sadness". This reminds everyone of "Everything is Fine", which was popular in the first half of the year, and it also makes the audience angry: Everything is fine? Obviously it’s not good! Why is the realistic theme easy to become a "title party"? The two hottest explosion dramas in 2019 so far are all realistic themes. Why have they all become "title parties"?

  Should Little Joy be renamed Old Sadness?

  And "Everything’s Fine", all of which are "title parties"!

  Netizens rated the two most deceptive titles of this year: "Everything is OK" and "Little Joy"! A week before the closing ceremony, the netizens who followed the drama vomited why the drama was called Little Joy, "Breaking up, unemployment, depression, depression, and liujing was sick", plus Eiko jumped into the sea at the climax of the whole drama, and three families jumped. What’s so happy about this? From the beginning of the play, several children in grade three are facing a series of life problems: family, study, hobbies, university, parents … … All kinds of contradictions and entanglements, but what the audience has been seeing for more than 40 episodes is still the anxiety of three families: Song Qian played by Tao Hong is the most controversial "controlling mother", and her husband’s betrayal made her put all her hopes on her daughter, which led a good girl to escape and resist by skipping classes and lying, and finally the contradictions broke out: Eiko was depressed, jumped into the sea and wanted to escape; Fiona Fang, played by Huang Lei, is a model warm dad. However, their husband and wife are both unemployed in middle age, their son doesn’t like studying, and they have a second child in the college entrance examination year. Liujing, the most gentle and quiet, first faced the couple’s "airborne" in his son’s third year of high school, and just made reconciliation with his son in various frictions but suffered from cancer … … God, every family is full of problems and tired! Because the original story is darker,Therefore, until the last episode, the audience was on tenterhooks: afraid that liujing’s cancer would die, afraid that Lei Er would not be admitted to Tsinghua, and afraid that the setting of the second child would go back to the heart-wrenching ending of "Pi of Youth" … … Some netizens "warned" screenwriter Huang Lei: If "Little Joy" fails, send him to "Chinese Restaurant" to cook for Huang Xiaoming!

  While "Little Joy" was teased by netizens and changed to "Old Sorrow", many netizens also associated it with "Everything’s Fine", which caused a heated discussion among the whole people in the first half of the year. I believe everyone still remembers the plot: all the men in the family are experts, the eldest brother is a good old man who muddles along, the second brother is a violent mambo, and the old father Su Daqiang made flowers in heaven. After all kinds of tossing and hurting, the netizens were once desperate.

  The audience broke their hearts for Lei Er’s dream of Tsinghua.

  Director: "Joy" is like "Looking for candy in the glass"

  On the night of the finale, "Leier’s mouth shape" remained high in hot search. Why? It turned out that when the audience found that Lei Er said, "Although I was admitted to Tsinghua and realized my mother’s dream, physics is my dream", the lip-synching didn’t match! Wen Jie’s mouth should say: "Lei Er, you are already great. Although you didn’t get into Tsinghua as an undergraduate, you can get into Tsinghua as a graduate student and Tsinghua as a doctor. You still have a chance!" This passage was later re-dubbed, that is to say, the audience didn’t want the sensible and excellent Lei Er’s dream to fail, and the screenwriter changed Lei Er’s ending in order to make everyone "happy", which broke the heart from the production team to the audience.

  Why do people care so much about whether Lei Er has been admitted to Tsinghua? This is also the reason why everyone is "worried" about the title, just as the netizen left a message saying: "Nine times out of ten, life is not satisfactory, only a little joy." The reason why "Little Joy" is popular is "poking the real pain point", and the audience feels the same. At the end of "Everything’s Fine" and "Little Joy", the children all like to mention the university notice, so why do the audience still complain about the "title party"? Because the process is too "heartfelt"! How realistic is this play? Huang Lei, the chief screenwriter, said frankly: The screenwriter doesn’t have to make it up, because everyone is around you. My screenwriter writes plays around me, and I tell them who is who one by one. As for the title of the play, he said with emotion: "The joy of China’s family lies in enduring, having fun after passing one level, passing a small level in the senior high school entrance examination and passing the college entrance examination. Because we are facing a background of great anxiety, we must find ourselves a little joy in this environment. " Director Wang Jun also explained the "title party" in the finale, "Life is like looking for candy in glass, and every grain is precious … … I hope this play will let you put aside some bitterness and anxiety for the time being and taste every sweetness that life has given us. "

  Compared with the sweet pet drama Xian Xia, a good realistic theme is that people often look at their own lives when watching the drama, so it is bound to be painful and uncomfortable, and then while spitting, cheering for Lei Er and Yingzi to be admitted to a prestigious school, and also crying for Su Daqiang who reconciled with his children.

  Good realistic drama, they are the biggest joy:

  A good actor can add drama and oil to his role.

  Whether it’s Little Joy or Everything’s Fine, there is a particularly interesting phenomenon: the audience has a very high degree of discussion, and the controversy about voicing is of course due to "empathy", but there is another point that is particularly important: a good actor is not only the prerequisite for the establishment of a realistic drama, but also the biggest "joy" in this industry.

  Tao Hong is the most discussed actor in A Little Joy, because his performance is so good that many netizens shouted to Xú Zhēng: Tao Hong belongs to everyone, and Tao Hong should be allowed to film more. In fact, Hai Qing and Yongmei, including Huang Lei and Yanhui Wang, all performed very well. However, due to the problem of role setting, Tao Hong and Sha Yi not only played the role alive, but also "upgraded" the role. Many viewers said: Song Qian and Qiao Weidong would definitely be scolded to death if Tao Hong and Sha Yi didn’t play them! Some people on the Internet commented that Sha Yi "has a simple old father’s breath, is kind, funny, and has no aggression, and he can also grease the role with his own ability". The role of Qiao Weidong is actually a greasy love rat, but Sha Yi has given this role a silly, unintelligent and funny sense of joy, which makes the audience hate it. Tao Hong’s performance of Song Qian is extremely suffocating, but Tao Hong’s performance is quite hierarchical and life-oriented, and it is somewhat delicate and touching, which makes people unconsciously stand in her position and understand. In the scene where Eiko watched the movie, she temporarily changed the script to add her own understanding, and finally was cut into the promotional film.

  Similar scenes can refer to Su Daqiang. The stalk of "I want to drink hand-ground coffee" is a play that Dahong Ni temporarily added. As a result, it became a classic expression pack. Su Daqiang was timid, cowardly and selfish, but Dahong Ni used his own understanding to resolve the outrageous characters, which made everyone suddenly see Meng! As a result, Su Daqiang became an independent IP. Su Mingcheng is also an annoying character, but Guo Jingfei actually performed a lovely thing besides the hatred of Ma Bao-nan … …

  A good actor can add drama and oil to the role, and the better and more realistic the actor plays, the more realistic the drama will resonate with the audience, which is why the audience is entangled in the "title party": they are too much like our life! So we want to see a happier life! However, Little Joy and Everything’s Fine just broke through the "story" of the previous family dramas, exposing family of origin’s scars and anxiety in the family of entering a higher school. The main characters have shortcomings and are even unpleasant, which makes the audience feel "abusive" and "uncomfortable", and at the same time, they are grateful for their little joy.

  Yangzi Evening News reporter zhangyan

First batch! Yun Qi’s boundless code fuzzy test system passed the fuzzy test capability evaluation of China Institute of Information and Communication.

Recently, Yun Qi Infinite Code Fuzzy Testing System participated in the standard evaluation of "Fuzzy Testing Architecture Capability Requirements" of China ICT Institute. In order to verify the safety capability of fuzzy test products in a more standard form, the "Capability Requirements of Fuzzy Test Architecture" standardizes the platform capability and engine capability of black-box and gray-box fuzzy tests, including 4 capability domains, 28 capability items and 246 capability indicators, and provides the overall guidance for the capability construction of fuzzy test platforms. According to the comprehensive performance of fuzzy test platform in different capability domains, it is divided into three capability levels: basic level, enhanced level and advanced level.

After the inspection by China Institute of Information and Communication Technology, the Infinite Code Fuzzy Testing System passed the index test of "Fuzzy Testing Architecture Capability Requirements" with the highest score, and its gray box platform capability domain and gray box engine capability domain both reached the "advanced level" requirement of fuzzy testing technology grading capability evaluation, and the product capability was highly recognized.

Software is the soul of a new generation of information technology, the foundation of the development of digital economy, and the key support for the construction of manufacturing power, network power and digital China. At present, the scale benefit of China’s software and information technology service industry is growing rapidly, and the innovation system of software and information technology service industry is basically established, which promotes the rapid development of new technologies, new products, new models and new formats, and accelerates the changes in lifestyle, production methods and social governance. However, with the increase of the total number of software, software quality accidents are still emerging.

As the leader of a new generation of intelligent fuzzy testing, Yun Qi Infinite has been focusing on the research and innovation of fuzzy testing technology since its establishment, and taking this as the core, it has built a series of products and services based on fuzzy testing, and is committed to helping enterprises solve the problem of security vulnerability mining in various scenarios, bringing more perfect and safer product service experience to enterprises.

1. Technological innovation: AIGC enables intelligent fuzzy testing.

The rapid development of GPT model has had a subversive impact on the production paradigm of various industries. As the leader of a new generation of intelligent fuzzy testing, Yun Qi Infinite takes the lead in integrating AIGC mode into products and empowering the software development stage, which has achieved remarkable results in the automatic generation of test cases and the automatic repair of vulnerabilities.

Security vulnerability detection: After AIGC is integrated into intelligent fuzzy testing, the generation process of test samples can be further optimized for specific input types and unknown defects, which greatly improves the quality and generation efficiency of test samples. Moreover, based on coverage guidance and other technologies, applications can be targeted for detection, code boundaries can be deeply explored, and known and unknown threats can be effectively detected.

Security vulnerability repair: Intelligent code fuzzy testing can accurately locate the defective code fragments and reproduce the causes of vulnerabilities. By using AIGC mode, the repaired code can be automatically generated by taking the detection results such as error code fragments as the input of the defect repair model. This method greatly improves the efficiency of defect repair and lowers the technical threshold of defect repair.

Generally speaking, through the deep integration of fuzzy testing and AIGC, Yun Qi Infinite Intelligent Fuzzy Testing Solution has greatly improved its capabilities in automation, testing depth, testing efficiency and defect repair, and opened a new chapter in intelligent security testing.

2. Yun Qi Infinite Product Service Matrix

Infinite code fuzzy test system

Based on intelligent fuzzy testing technology, Yun Qi Infinitus integrates GPT model, and develops and designs the infinite code fuzzy testing system on the basis of mutation algorithm, genetic algorithm, coverage guidance and many other technologies. Infinite code fuzzy testing system can be applied to development, testing, integration and other links, and it can detect the security of source code/binary files. Compared with the automatic security detection method of traditional detection tools, it can not only efficiently mine and detect and analyze "known and unknown" vulnerabilities, but also integrate AIGC mode, which can automatically generate repair schemes and revised security code fragments, greatly reducing the defect repair time and manual repair cost.

At present, independent test mode and CI/CD integration mode are supported.

Compared with traditional security detection tools, the boundless code fuzzy testing system has four advantages:

1) Detection of zero false positives and reproducible vulnerabilities

The testing method based on dynamic execution ensures that all detected defects are locatable, reproducible and verifiable, and the false positive rate approaches zero.

2) The test granularity is finer and the coverage of the scene is more complete.

Intelligent fuzzy testing based on AIGC, relying on AI genetic mutation algorithm and coverage guidance technology in the sample generation stage, can automatically generate massive (billion-level) high-quality test cases, the overall granularity will be finer, there will be more test points, and the location will be more accurate, which significantly improves the test effect and coverage. This scheme can not only be applied to Web application detection, but also be used in detection scenarios with higher test granularity requirements such as protocols, operating systems and databases.

3) Accurate detection of unknown vulnerabilities

By using AIGC to generate various types of distortion test data, the diversity and complexity of Fuzzing test can be increased, and more types of defects and unknown 0-0day vulnerabilities can be found. For example, by generating a string containing special characters or embedded commands, you can test the fault tolerance and security of the program for different input data.

4) Greatly reduce the cost of bug repair.

By combining AIGC with fuzzy testing, we can generate vulnerability repair suggestions faster and further improve the efficiency of vulnerability repair. Moreover, fuzzy testing with AIGC can realize the closed loop of the whole process of automatic vulnerability mining and repair, greatly improve the work efficiency of testers, and thus save the repair cost.

Infinite Protocol Fuzzy Test System

Infinite protocol fuzzy test system is a black-box protocol fuzzy test system independently developed by Yun Qi Infinite. By providing unexpected input to the target and monitoring abnormal results, it can automatically detect system defects and verify the protocol function, and help enterprises realize automatic security detection from the source, thus improving the security and robustness of protocol application.

The advantages of accurate, intelligent and non-invasive products are as follows:

1) Rich protocol support

Covers nearly 100 mainstream network protocols and supports the creation of custom protocol models;

2) Fully automatic safety inspection

Test cases are automatically generated, test strategies are automatically optimized, and detected vulnerabilities are automatically verified;

3) unknown problems, defense in advance

Massive variation test cases, support the detection of known vulnerabilities, and be good at discovering unknown vulnerabilities;

4) Rich test reports

Provide accurate reports, including key information such as fault classification, repair suggestions and vulnerability details;

5) Eliminate false alarm noise in detection.

Simulate the real running environment of the program to ensure that all detected defects can be reproduced and 0 false positives;

6) Non-invasive

Black-box detection method is adopted, which does not invade the system or engineering code and finds deep loopholes;

Flawless software defect analysis system

Innocent software defect analysis system is a self-developed static source code analysis tool. Combining deep software analysis method and deep learning method, it can detect a large number of deep security vulnerabilities that existing software security testing tools cannot detect, and effectively eliminate a large number of false positives.

1) The detection accuracy is "more accurate"

Intelligent learning automatically eliminates false positives, and the false positive rate is only 1/3 of other products.

2) The detection speed is "faster"

The program analysis engine with independent patent technology and a variety of innovative static analysis technologies shorten the detection time by 1/3.

3) The detection depth is "deeper"

Support cross-file, cross-class and cross-function defect/vulnerability detection of tens of millions of lines of code.

4) Detect vulnerabilities "more"

Can find more known/unknown deep security vulnerabilities.

Dust-free software component analysis system

An all-round intelligent software component analysis platform is built based on the concept of "security moving to the left" and DevSCAOps. The platform has four core component analysis engines: source code, component dependency, binary and container mirroring, which can quickly and accurately identify the third-party open source components used in the software, and then identify the potential security vulnerabilities and license information in the software through the correlation analysis technology, comprehensively judge the related risks, and give suggestions on how to repair the related risks, and rely on the SBOM account management ability to empower enterprises to make internal software.

The platform aims to empower enterprises with the ability of open source security and compliance governance, help enterprises achieve the knowability and controllability of software products in the practical sense, and escort enterprise network security.

Compared with the traditional SCA products, the clean software component analysis system can detect various types of targets, support file-level vulnerability homology analysis, support code autonomy analysis of Xinchuang software, and update data at high frequency, and provide standard SBOM list generation and management functions to effectively support users’ business needs.

1) Software component analysis, which supports source code, component dependency, binary file and container mirroring at the same time.

2) Vulnerability analysis, which supports component vulnerability correlation analysis and file-level vulnerability homology analysis.

3) License compliance analysis, while supporting component risk, conflict risk and tampering risk.

4) Support code copyright compliance analysis

5) Support code autonomy analysis

6)DevOps tool chain support

7) Data update frequency is daily update.

8) Software asset management, which supports the generation and management of SBOM list in international standard SPDX format.

Intelligent fuzzy test service

Relying on the service team’s accumulated experience in the security industry for more than ten years, Yun Qi Infinite has brought innovative intelligent fuzzy testing services to enterprises, including Internet of Things /IOT security testing services, vehicle equipment/vehicle networking security testing, service component security testing and directional vulnerability mining services, which help enterprises to build a more perfect security line and provide more comprehensive security solutions.

The advantages of fuzzy test service include the following:

1) Multi-field professional services: Yun Qi Infinite’s professional teams in the fields of network security, Internet of Things /IoT, cloud computing, big data and blockchain provide customers with high-quality technical services.

2) Rich expert experience: With rich practical experience, Yun Qi’s boundless expert team can quickly understand and locate customers’ core needs, reduce communication costs, and provide customized solutions for customers.

3) Advanced technical means: Yun Qi’s boundless security experts have won many awards in the top international information security competitions, and presented topics in world-renowned public meetings for many times, and their technical level is at the cutting edge in the industry.

4) Strict quality control: Yun Qi Infinite Security Service has established a perfect quality control system, with a complete quality control scheme from project start-up, demand analysis, development, delivery and maintenance, and the project manager will follow up all the way to ensure that every project of customers can be completed on time, with high quality and high standard.

As an advanced method of vulnerability mining and stability detection, the exploration of fuzzy testing technology continues. Next, Yun Qi Infinite will continue to deepen the fuzzy testing technology, build a more perfect product service matrix, and devote itself to the improvement of software development safety and software quality, provide customers with solutions that meet industry standards and use scenarios, and jointly promote the technical concept of system stability represented by fuzzy testing to fill the gap between technical theory and practice.

About the infinity of Yun Qi

Yun Qi Infinite is a new generation of AI-enabled software supply chain security practitioner, who is committed to promoting intelligent security detection and automatic defect repair of AI-enabled information systems. The team has gathered innovative talents in the security field from well-known universities such as Tsinghua and Beihou University, as well as head IT companies such as Huawei and Tencent. It has world-class automatic vulnerability detection and mining capabilities, and its products cover intelligent fuzzy testing, source code defect analysis, software component analysis, and intelligent security knowledge base.

Yun Qi Infinite has obtained dozens of software copyrights and patents, passed ISO 9001, ISO 20000, ISO 27001 and other certifications, participated in the formulation of more than 20 national and industrial standards, and served many industries such as energy, finance, communication and automobile. Since its establishment, the company has completed several rounds of tens of millions of financing.

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[Editor: Zhong Jingwen]